TY - JOUR
T1 - Bidirectional ephrin signaling in bone
AU - Rundle, Charles H.
AU - Xing, Weirong
AU - Lau, Kin-Hing W.
AU - Mohan, Subburaman
N1 - The interaction between ephrin ligands (efn) and their receptors (Eph) is capable of inducing forward signaling, from ligand to receptor, as well as reverse signaling, from receptor to ligand. The ephrins are widely expressed in many tissues, where they mediate cell migration and adherence, properties that make the efn-Eph signaling critically important in establishing and maintaining tissue boundaries.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - The interaction between ephrin ligands (efn) and their receptors (Eph) is capable of inducing forward signaling, from ligand to receptor, as well as reverse signaling, from receptor to ligand. The ephrins are widely expressed in many tissues, where they mediate cell migration and adherence, properties that make the efn-Eph signaling critically important in establishing and maintaining tissue boundaries. The efn-Eph system has also received considerable attention in skeletal tissues, as ligand and receptor combinations are predicted to mediate interactions between the different types of cells that regulate bone development and homeostasis. This review summarizes our current understanding of efn-Eph signaling with a particular focus on the expression and functions of ephrins and their receptors in bone.
AB - The interaction between ephrin ligands (efn) and their receptors (Eph) is capable of inducing forward signaling, from ligand to receptor, as well as reverse signaling, from receptor to ligand. The ephrins are widely expressed in many tissues, where they mediate cell migration and adherence, properties that make the efn-Eph signaling critically important in establishing and maintaining tissue boundaries. The efn-Eph system has also received considerable attention in skeletal tissues, as ligand and receptor combinations are predicted to mediate interactions between the different types of cells that regulate bone development and homeostasis. This review summarizes our current understanding of efn-Eph signaling with a particular focus on the expression and functions of ephrins and their receptors in bone.
UR - https://www.sciencedirect.com/science/article/pii/S2405525516300139
UR - https://www.mendeley.com/catalogue/dfabf2c1-e89e-3812-abd9-ba308ec5994f/
U2 - 10.1016/J.AFOS.2016.05.002
DO - 10.1016/J.AFOS.2016.05.002
M3 - Review article
C2 - 30775469
VL - 2
SP - 65
EP - 76
JO - Osteoporosis and sarcopenia
JF - Osteoporosis and sarcopenia
IS - 2
ER -