TY - CHAP
T1 - Beneficial Effect of Hyperbaric Oxygenation After Neonatal Germinal Matrix Hemorrhage
AU - Lekic, Tim
AU - Manaenko, Anatol
AU - Rolland, William
AU - Ostrowski, Robert P.
AU - Virbel, Kelly
AU - Tang, Jiping
AU - Zhang, John H.
N1 - Funding Information:
Acknowledgements This study was partially supported by a grant (NS053407) from the National Institutes of Health to J.H.Z. Conflict of interest statement
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Background: Germinal matrix hemorrhage (GMH) is a potentially devastating neurological disease of very low birth weight premature infants. This leads to post-hemorrhagic hydrocephalus, cerebral palsy, and mental retardation. Hyperbaric oxygen (HBO) treatment is a broad neuroprotectant after brain injury. This study investigated the therapeutic effect of HBO after neonatal GMH. Methods: Neonatal rats underwent stereotaxic infusion of clostridial collagenase into the right germinal matrix (anterior caudate) brain region. Cognitive function was assessed at 3 weeks, and then sensorimotor, cerebral, cardiac, and splenic growths were measured 1 week thereafter. Results: Hyperbaric oxygen (HBO) treatment markedly improved upon the mental retardation and cerebral palsy outcome measurements in rats at the juvenile developmental stage. The administration of HBO early after neonatal GMH also normalized brain atrophy, splenomegaly, and cardiac hypertrophy 1 month after injury. Conclusion: This study supports the role of hyperbaric oxygen (HBO) treatment in the early period after neonatal GMH. HBO is an effective strategy to help protect the infant's brain from the post-hemorrhagic consequences of brain atrophy, mental retardation, and cerebral palsy. Further studies are necessary to determine the mechanistic basis of these neuroprotective effects. © 2011 Springer-Verlag/Wien.
AB - Background: Germinal matrix hemorrhage (GMH) is a potentially devastating neurological disease of very low birth weight premature infants. This leads to post-hemorrhagic hydrocephalus, cerebral palsy, and mental retardation. Hyperbaric oxygen (HBO) treatment is a broad neuroprotectant after brain injury. This study investigated the therapeutic effect of HBO after neonatal GMH. Methods: Neonatal rats underwent stereotaxic infusion of clostridial collagenase into the right germinal matrix (anterior caudate) brain region. Cognitive function was assessed at 3 weeks, and then sensorimotor, cerebral, cardiac, and splenic growths were measured 1 week thereafter. Results: Hyperbaric oxygen (HBO) treatment markedly improved upon the mental retardation and cerebral palsy outcome measurements in rats at the juvenile developmental stage. The administration of HBO early after neonatal GMH also normalized brain atrophy, splenomegaly, and cardiac hypertrophy 1 month after injury. Conclusion: This study supports the role of hyperbaric oxygen (HBO) treatment in the early period after neonatal GMH. HBO is an effective strategy to help protect the infant's brain from the post-hemorrhagic consequences of brain atrophy, mental retardation, and cerebral palsy. Further studies are necessary to determine the mechanistic basis of these neuroprotective effects. © 2011 Springer-Verlag/Wien.
KW - Hyperbaric oxygenation
KW - Neurological deficits
KW - Stroke, experimental
KW - Animals, Newborn
KW - Cerebral Hemorrhage/chemically induced
KW - Hyperbaric Oxygenation/methods
KW - Rats
KW - Cognition Disorders/etiology
KW - Nervous System Diseases/etiology
KW - Rats, Sprague-Dawley
KW - Neuropsychological Tests
KW - Pregnancy
KW - Developmental Disabilities/etiology
KW - Animals
KW - Analysis of Variance
KW - Collagenases/toxicity
KW - Female
KW - Maze Learning/drug effects
KW - Organ Size/drug effects
KW - Atrophy/etiology
KW - Movement/physiology
KW - Disease Models, Animal
UR - http://www.ncbi.nlm.nih.gov/pubmed/21725764
UR - https://www.mendeley.com/catalogue/aaa9413e-81e9-3a25-b6c1-78f3bc04eda3/
U2 - 10.1007/978-3-7091-0693-8_42
DO - 10.1007/978-3-7091-0693-8_42
M3 - Chapter
C2 - 21725764
SN - 9783709106921
SN - 978-3-7091-2007-1
T3 - Acta Neurochirurgica, Supplementum
SP - 253
EP - 257
BT - Intracerebral Hemorrhage Research
PB - Springer Vienna
ER -