Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells

  • Yujun Wang
  • , Ernest Han
  • , Quanhua Xing
  • , Jin Yan
  • , Amanda Arrington
  • , Charles Wang
  • , Dylan Tully
  • , Claudia M. Kowolik
  • , David M. Lu
  • , Paul H. Frankel
  • , Jing Zhai
  • , Wei Wen
  • , David Horne
  • , M. L.Richard Yip
  • , John H. Yim

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)170-179
Number of pages10
JournalCancer Letters
Volume358
Issue number2
DOIs
StatePublished - Mar 28 2015
Externally publishedYes

ASJC Scopus Subject Areas

  • Oncology
  • Cancer Research

Keywords

  • Baicalein
  • Cellular stress
  • DDIT4
  • IRF1
  • MTOR
  • Up-Regulation
  • Antineoplastic Agents/administration & dosage
  • Humans
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic/drug effects
  • Transcription Factors/genetics
  • Tumor Suppressor Protein p53/genetics
  • Neoplasms/genetics
  • Protein Kinase Inhibitors/administration & dosage
  • TOR Serine-Threonine Kinases/antagonists & inhibitors
  • Animals
  • Time Factors
  • Cell Line, Tumor
  • Flavanones/administration & dosage
  • Female
  • Transcription, Genetic
  • Mice
  • Cell Proliferation/drug effects
  • Disease Models, Animal

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