Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells

Yujun Wang, Ernest Han, Quanhua Xing, Jin Yan, Amanda Arrington, Charles Wang, Dylan Tully, Claudia M. Kowolik, David M. Lu, Paul H. Frankel, Jing Zhai, Wei Wen, David Horne, M. L.Richard Yip, John H. Yim

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)170-179
Number of pages10
JournalCancer Letters
Volume358
Issue number2
DOIs
StatePublished - Mar 28 2015
Externally publishedYes

ASJC Scopus Subject Areas

  • Oncology
  • Cancer Research

Keywords

  • Baicalein
  • Cellular stress
  • DDIT4
  • IRF1
  • MTOR
  • Up-Regulation
  • Antineoplastic Agents/administration & dosage
  • Humans
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic/drug effects
  • Transcription Factors/genetics
  • Tumor Suppressor Protein p53/genetics
  • Neoplasms/genetics
  • Protein Kinase Inhibitors/administration & dosage
  • TOR Serine-Threonine Kinases/antagonists & inhibitors
  • Animals
  • Time Factors
  • Cell Line, Tumor
  • Flavanones/administration & dosage
  • Female
  • Transcription, Genetic
  • Mice
  • Cell Proliferation/drug effects
  • Disease Models, Animal

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