TY - JOUR
T1 - Autoimmune neutropenia in multiple myeloma and the role of clonal t-cell expansion
T2 - Evidence of cross-talk between B-cell and T-cell lineages?
AU - Aryal, Madan Raj
AU - Bhatt, Vijaya Raj
AU - Tandra, Pavankumar
AU - Krishnamurthy, Jairam
AU - Yuan, Ji
AU - Greiner, Timothy C.
AU - Akhtari, Mojtaba
N1 - TY - JOUR T1 - Autoimmune neutropenia in multiple myeloma and the role of clonal t-cell expansion T2 - Evidence of cross-talk between B-cell and T-cell lineages?
PY - 2014/2
Y1 - 2014/2
N2 - Autoimmune neutropenia (AIN), characterized by an absolute neutrophil count below 1500 cells/mL in the presence of autoantibodies directed against neutrophil antigens, can be secondary to a variety of underlying diseases, such as connective tissue diseases, infections, and malignancies. However, it has not been reported in association with multiple myeloma (MM). We report a case of AIN in a patient with MM who also had a population of small lymphocytes with T-cell receptor gamma chain gene rearrangements. We also review other autoimmune manifestations of MM, the role of T-cell receptor gene rearrangement in AIN, and the implications of AIN in the management of MM. AIN can develop as a consequence of MM, and it is likely underdiagnosed because of the diagnostic difficulties. AIN can increase the risk of recurrent or serious infections in patients undergoing chemotherapy.
AB - Autoimmune neutropenia (AIN), characterized by an absolute neutrophil count below 1500 cells/mL in the presence of autoantibodies directed against neutrophil antigens, can be secondary to a variety of underlying diseases, such as connective tissue diseases, infections, and malignancies. However, it has not been reported in association with multiple myeloma (MM). We report a case of AIN in a patient with MM who also had a population of small lymphocytes with T-cell receptor gamma chain gene rearrangements. We also review other autoimmune manifestations of MM, the role of T-cell receptor gene rearrangement in AIN, and the implications of AIN in the management of MM. AIN can develop as a consequence of MM, and it is likely underdiagnosed because of the diagnostic difficulties. AIN can increase the risk of recurrent or serious infections in patients undergoing chemotherapy.
KW - Anti-neutrophil antibody
KW - Filgrastim
KW - T-cell receptor gene rearrangement
KW - T-lymphocyte
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U2 - 10.1016/j.clml.2013.08.002
DO - 10.1016/j.clml.2013.08.002
M3 - Article
C2 - 24183500
SN - 2152-2650
VL - 14
SP - e19-e23
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 1
ER -