Atractyloside induces low contractile reaction of arteriolar smooth muscle through mitochondrial damage

  • Rui Song
  • , Huining Bian
  • , Xuliang Huang
  • , Ke Seng Zhao

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)402-408
Number of pages7
JournalJournal of Applied Toxicology
Volume32
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

ASJC Scopus Subject Areas

  • Toxicology

Keywords

  • Arteriolar smooth muscle cells
  • Atractyloside
  • Contractile reaction
  • Cytotoxicity
  • Mitochondrial dysfunction
  • Enzyme Inhibitors/toxicity
  • Atractyloside/toxicity
  • Mesentery/blood supply
  • Mitochondrial Permeability Transition Pore
  • Rats, Wistar
  • Cell Membrane/drug effects
  • Mitochondrial Membrane Transport Proteins/drug effects
  • Apoptosis/drug effects
  • Cells, Cultured
  • Adenosine Triphosphate/metabolism
  • Rats
  • Myocytes, Smooth Muscle/drug effects
  • Muscle, Smooth, Vascular/drug effects
  • Arterioles/drug effects
  • Dose-Response Relationship, Drug
  • Animals
  • Mitochondria/drug effects
  • Muscle Contraction/drug effects
  • Membrane Potentials/drug effects

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