TY - JOUR
T1 - Arachidonic acid metabolites in otitis media pathogenesis
AU - Jung, T. T.K.
N1 - Arachidonic acid metabolites in otitis media pathogenesis
PY - 1988
Y1 - 1988
N2 - Arachidonic acid (AA), which is derived from phospholipids of cell membrane, is metabolized enzymatically into two pathways, one trough cyclooxygenase and the other trough lipoxygenase. Cyclooxygenase products include different prostaglandins (PGs) and thromboxane (Tx), and lipoxygenase products include hydroxyeicosatetraenoic acids (HETEs) and leukotrienes (LTs). Corticosteroids inhibit release of AA, and nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the activity of cyclooxygenase. Among the various inflammatory mediators of otitis media, AA metabolites - both PGs and LTs - appear to play a major role in the pathogenesis of otitis media. This paper will review studies on AA metabolites in the pathogenesis otitis media. These studies include assays of AA metabolites (eicosanoids) in the middle ear effusions (MEEs) and middle ear tissues, identification of AA metabolites in otitis media, localization of cyclooxygenase in the middle ear mucosa (MEM), effects of exogenous PG on the composition of MEE, and therapeutic uses of inhibitors of AA metabolism.
AB - Arachidonic acid (AA), which is derived from phospholipids of cell membrane, is metabolized enzymatically into two pathways, one trough cyclooxygenase and the other trough lipoxygenase. Cyclooxygenase products include different prostaglandins (PGs) and thromboxane (Tx), and lipoxygenase products include hydroxyeicosatetraenoic acids (HETEs) and leukotrienes (LTs). Corticosteroids inhibit release of AA, and nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the activity of cyclooxygenase. Among the various inflammatory mediators of otitis media, AA metabolites - both PGs and LTs - appear to play a major role in the pathogenesis of otitis media. This paper will review studies on AA metabolites in the pathogenesis otitis media. These studies include assays of AA metabolites (eicosanoids) in the middle ear effusions (MEEs) and middle ear tissues, identification of AA metabolites in otitis media, localization of cyclooxygenase in the middle ear mucosa (MEM), effects of exogenous PG on the composition of MEE, and therapeutic uses of inhibitors of AA metabolism.
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U2 - 10.1177/00034894880970s305
DO - 10.1177/00034894880970s305
M3 - Article
C2 - 3132884
SN - 0003-4894
VL - 97
SP - 14
EP - 18
JO - Annals of Otology, Rhinology and Laryngology
JF - Annals of Otology, Rhinology and Laryngology
IS - 3 II SUPPL. 132
ER -