Applications of accelerator MS in pediatric drug evaluation

L. T. Vuong; A. B. Blood; J. S. Vogel; M. E. Anderson; B. Goldstein

doi:10.4155/bio.12.173

Applications of accelerator MS in pediatric drug evaluation

L. T. Vuong, A. B. Blood, J. S. Vogel, M. E. Anderson, B. Goldstein

Research output: Contribution to journal › Review article › peer-review

Abstract

Accelerator MS (AMS) provides a novel method for obtaining and analyzing pharmacokinetics and pharmacodynamics in children. This paper reviews the scientific and ethical rationale for AMS in pediatric trials, the regulatory framework and general considerations with some specific examples of pediatric clinical trials using AMS. Microdosing in the context of this article refers to studies using a negligible amount (nanocuries) of ¹⁴C as tracer, and AMS as a quantitative technique. The technology is by no means a panacea for the deficiency in pediatric clinical research; however, it lessens the challenges and provides the most quantitative tool for pediatric pharmacology studies.

Original language	English
Pages (from-to)	1871-1882
Number of pages	12
Journal	Bioanalysis
Volume	4
Issue number	15
DOIs	https://doi.org/10.4155/bio.12.173
State	Published - Aug 2012

ASJC Scopus Subject Areas

Analytical Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Clinical Biochemistry
Medical Laboratory Technology

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Applications of accelerator MS in pediatric drug evaluation

Abstract

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