TY - JOUR
T1 - Angiopoietin-like 4
T2 - A double-edged sword in atherosclerosis and ischemic stroke?
AU - Xu, Liang
AU - Guo, Zhen Ni
AU - Yang, Yi
AU - Xu, Jun
AU - Burchell, Sherrefa R.
AU - Tang, Jiping
AU - Zhang, Jianmin
AU - Xu, Jing
AU - Zhang, John H.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Ischemic stroke is one of the leading causes of death in the world, and thus is a major public health concern. Atherosclerosis, also known as atherogenesis, is a crucial risk factor for cerebral ischemia, yet how it develops remains largely unknown. It has been found, however, that angiopoietin-like protein 4 (ANGPTL4), a protein expressed in vascular endothelial cells, plays a role in the pathophysiology of atherosclerosis and may therefore be involved in ischemic stroke. ANGPTL4 activity is associated with endothelial cell integrity, inflammation, oxidative stress, and lipid metabolism. ANGPTL4 also serves as a potent inhibitor of the lipoprotein lipase, and may inhibit atherogenesis via regulating inflammatory signaling and lipid metabolism. In addition, ANGPTL4 plays a role in the regulation of oxidative stress. However, there currently exists a controversy on the role of ANGPTL4 in endothelial cells. Some studies indicate that ANGPTL4 can protect the integrity of endothelial cells, while others have shown that it can be destructive to the endothelium, thereby leading to the initiation of atherosclerosis. Thus, the effects of ANGPTL4 on development of atherosclerosis and thereby ischemic stroke, are undefined. Further research is needed to better understand ANGPTL4-mediated signaling pathways in endothelial function and to determine its potentials as therapeutic target for atherosclerosis and ischemic stroke.
AB - Ischemic stroke is one of the leading causes of death in the world, and thus is a major public health concern. Atherosclerosis, also known as atherogenesis, is a crucial risk factor for cerebral ischemia, yet how it develops remains largely unknown. It has been found, however, that angiopoietin-like protein 4 (ANGPTL4), a protein expressed in vascular endothelial cells, plays a role in the pathophysiology of atherosclerosis and may therefore be involved in ischemic stroke. ANGPTL4 activity is associated with endothelial cell integrity, inflammation, oxidative stress, and lipid metabolism. ANGPTL4 also serves as a potent inhibitor of the lipoprotein lipase, and may inhibit atherogenesis via regulating inflammatory signaling and lipid metabolism. In addition, ANGPTL4 plays a role in the regulation of oxidative stress. However, there currently exists a controversy on the role of ANGPTL4 in endothelial cells. Some studies indicate that ANGPTL4 can protect the integrity of endothelial cells, while others have shown that it can be destructive to the endothelium, thereby leading to the initiation of atherosclerosis. Thus, the effects of ANGPTL4 on development of atherosclerosis and thereby ischemic stroke, are undefined. Further research is needed to better understand ANGPTL4-mediated signaling pathways in endothelial function and to determine its potentials as therapeutic target for atherosclerosis and ischemic stroke.
KW - Angiopoietin-like 4
KW - Atherosclerosis
KW - Endothelial cell
KW - Inflammation
KW - Ischemic stroke
KW - Lipid metabolism
KW - Oxidative stress
KW - Oxidative Stress/physiology
KW - Humans
KW - Stroke/etiology
KW - Atherosclerosis/metabolism
KW - Animals
KW - Brain Ischemia/complications
KW - Inflammation/etiology
KW - Angiopoietin-Like Protein 4
KW - Lipid Metabolism/physiology
KW - Angiopoietins/metabolism
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UR - https://www.mendeley.com/catalogue/5c98381f-1527-3e2d-aafd-5f01ccc0d4e5/
U2 - 10.1016/j.expneurol.2015.05.020
DO - 10.1016/j.expneurol.2015.05.020
M3 - Article
C2 - 26033474
SN - 0014-4886
VL - 272
SP - 61
EP - 66
JO - Experimental Neurology
JF - Experimental Neurology
ER -