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An osteoclastic protein-tyrosine phosphatase regulates the β3-integrin, syk, and shp1 signaling through respective src-dependent phosphorylation in osteoclasts

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)C1676-86
Number of pages11
JournalAmerican Journal of Physiology - Cell Physiology
Volume302
Issue number11
DOIs
StatePublished - Jun 1 2012

ASJC Scopus Subject Areas

  • Physiology
  • Cell Biology

Keywords

  • Rac
  • Resorption
  • Trapping mutant pull-down
  • Vav
  • siRNA
  • Phosphorylation
  • rac GTP-Binding Proteins/biosynthesis
  • Integrin beta3/genetics
  • Protein-Tyrosine Kinases/genetics
  • Protein Tyrosine Phosphatases/genetics
  • RNA Interference
  • Syk Kinase
  • Cell Line
  • Osteoclasts/metabolism
  • Bone Resorption
  • Signal Transduction
  • Neuropeptides/biosynthesis
  • Phospholipase C gamma/biosynthesis
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism
  • Animals
  • Intracellular Signaling Peptides and Proteins/genetics
  • Mice
  • RNA, Small Interfering
  • Recombinant Fusion Proteins/metabolism
  • rac1 GTP-Binding Protein
  • Proto-Oncogene Proteins c-vav/biosynthesis
  • src-Family Kinases/metabolism

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