An integrated, multiregional, and multimodal cell atlas of Alzheimer’s disease

Kyle J. Travaglini; Yi Ding; Mariano I. Gabitto; Nadia Postupna; Joseph T. Mahoney; Eitan S. Kaplan; Jeff Goldy; Anish Bhaswanth Chakka; Andreas Tjaernberg; Omar Kana; Anamika Agrawal; Ming Xiao; Tejas S. Bajwa; Victoria M. Rachleff; Nick Dee; Erica J. Melief; Jeanelle Ariza; Brian Long; Emily Gelfand; Samuel T. Barlow; Darren Bertagnolli; Jazmin Campos; John S. Campos; Thanh Cardenas; Tamara Casper; Rushil Chakrabarty; Michael Clark; Nasmil J.Valera Cuevas; Martin Darvas; Song Lin Ding; Christine L.Mac Donald; Rebecca Ferrer; Jessica Gloe; Junitta Guzman; Windy Ho; Lisa M. Keene; Sarah Khawand; Mitchell D. Kilgore; Amanda Keen; Mckaila Leytze; Zoe Maltzer; Naomi Martin; Rachel McCue; Delissa McMillen; Gonzalo Mena; Emma Meyerdierks; Kelly P. Meyers; Mark Montine; Beagan Nguy; Nicholas Peña; Amber L. Nolan; Julie K. Nyhus; Paul A. Olsen; Maiya Pacleb; Chelsea M. Pagan; Trangthanh Pham; Christine Rimorin; Giuseppe A. Saldi; Sarah Walling-Bell; Aimee M. Schantz; Nadiya V. Shapovalova; Staci A. Sorensen; Susan M. Sunkin; Michael Tieu; Amy Torkelson; Jack Waters; Angela M. Wilson; David R. Haynor; Nicole M. Gatto; Suman Jayadev; Shubhabrata Mukherjee; Paul K. Crane; Caitlin S. Latimer; Boaz P. Levi; Kimberly A. Smith; Thomas J. Grabowski; Eric B. Larson; Jennie L. Close; Rebecca D. Hodge; Jeremy A. Miller; Michael J. Hawrylycz; C. Dirk Keene; Ed S. Lein

doi:10.1002/alz70861_108223

An integrated, multiregional, and multimodal cell atlas of Alzheimer’s disease

Kyle J. Travaglini
, Yi Ding
, Mariano I. Gabitto
, Nadia Postupna
, Joseph T. Mahoney
, Eitan S. Kaplan
, Jeff Goldy
, Anish Bhaswanth Chakka
, Andreas Tjaernberg
, Omar Kana
, Anamika Agrawal
, Ming Xiao
, Tejas S. Bajwa
, Victoria M. Rachleff
, Nick Dee
, Erica J. Melief
, Jeanelle Ariza
, Brian Long
, Emily Gelfand
, Samuel T. Barlow

Darren Bertagnolli, Jazmin Campos, John S. Campos, Thanh Cardenas, Tamara Casper, Rushil Chakrabarty, Michael Clark, Nasmil J.Valera Cuevas, Martin Darvas, Song Lin Ding, Christine L.Mac Donald, Rebecca Ferrer, Jessica Gloe, Junitta Guzman, Windy Ho, Lisa M. Keene, Sarah Khawand, Mitchell D. Kilgore, Amanda Keen, Mckaila Leytze, Zoe Maltzer, Naomi Martin, Rachel McCue, Delissa McMillen, Gonzalo Mena, Emma Meyerdierks, Kelly P. Meyers, Mark Montine, Beagan Nguy, Nicholas Peña, Amber L. Nolan, Julie K. Nyhus, Paul A. Olsen, Maiya Pacleb, Chelsea M. Pagan, Trangthanh Pham, Christine Rimorin, Giuseppe A. Saldi, Sarah Walling-Bell, Aimee M. Schantz, Nadiya V. Shapovalova, Staci A. Sorensen, Susan M. Sunkin, Michael Tieu, Amy Torkelson, Jack Waters, Angela M. Wilson, David R. Haynor, Nicole M. Gatto, Suman Jayadev, Shubhabrata Mukherjee, Paul K. Crane, Caitlin S. Latimer, Boaz P. Levi, Kimberly A. Smith, Thomas J. Grabowski, Eric B. Larson, Jennie L. Close, Rebecca D. Hodge, Jeremy A. Miller, Michael J. Hawrylycz, C. Dirk Keene, Ed S. Lein

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	e108223
Journal	Alzheimer's and Dementia
Volume	21
Issue number	S7
DOIs	https://doi.org/10.1002/alz70861_108223
State	Published - Dec 1 2025
Externally published	Yes

ASJC Scopus Subject Areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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Travaglini, K. J., Ding, Y., Gabitto, M. I., Postupna, N., Mahoney, J. T., Kaplan, E. S., Goldy, J., Chakka, A. B., Tjaernberg, A., Kana, O., Agrawal, A., Xiao, M., Bajwa, T. S., Rachleff, V. M., Dee, N., Melief, E. J., Ariza, J., Long, B., Gelfand, E., ... Lein, E. S. (2025). An integrated, multiregional, and multimodal cell atlas of Alzheimer’s disease. Alzheimer's and Dementia, 21(S7), e108223. https://doi.org/10.1002/alz70861_108223

Travaglini, KJ, Ding, Y, Gabitto, MI, Postupna, N, Mahoney, JT, Kaplan, ES, Goldy, J, Chakka, AB, Tjaernberg, A, Kana, O, Agrawal, A, Xiao, M, Bajwa, TS, Rachleff, VM, Dee, N, Melief, EJ, Ariza, J, Long, B, Gelfand, E, Barlow, ST, Bertagnolli, D, Campos, J, Campos, JS, Cardenas, T, Casper, T, Chakrabarty, R, Clark, M, Cuevas, NJV, Darvas, M, Ding, SL, Donald, CLM, Ferrer, R, Gloe, J, Guzman, J, Ho, W, Keene, LM, Khawand, S, Kilgore, MD, Keen, A, Leytze, M, Maltzer, Z, Martin, N, McCue, R, McMillen, D, Mena, G, Meyerdierks, E, Meyers, KP, Montine, M, Nguy, B, Peña, N, Nolan, AL, Nyhus, JK, Olsen, PA, Pacleb, M, Pagan, CM, Pham, T, Rimorin, C, Saldi, GA, Walling-Bell, S, Schantz, AM, Shapovalova, NV, Sorensen, SA, Sunkin, SM, Tieu, M, Torkelson, A, Waters, J, Wilson, AM, Haynor, DR, Gatto, NM, Jayadev, S, Mukherjee, S, Crane, PK, Latimer, CS, Levi, BP, Smith, KA, Grabowski, TJ, Larson, EB, Close, JL, Hodge, RD, Miller, JA, Hawrylycz, MJ, Keene, CD & Lein, ES 2025, 'An integrated, multiregional, and multimodal cell atlas of Alzheimer’s disease', Alzheimer's and Dementia, vol. 21, no. S7, pp. e108223. https://doi.org/10.1002/alz70861_108223

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author = "Travaglini, \{Kyle J.\} and Yi Ding and Gabitto, \{Mariano I.\} and Nadia Postupna and Mahoney, \{Joseph T.\} and Kaplan, \{Eitan S.\} and Jeff Goldy and Chakka, \{Anish Bhaswanth\} and Andreas Tjaernberg and Omar Kana and Anamika Agrawal and Ming Xiao and Bajwa, \{Tejas S.\} and Rachleff, \{Victoria M.\} and Nick Dee and Melief, \{Erica J.\} and Jeanelle Ariza and Brian Long and Emily Gelfand and Barlow, \{Samuel T.\} and Darren Bertagnolli and Jazmin Campos and Campos, \{John S.\} and Thanh Cardenas and Tamara Casper and Rushil Chakrabarty and Michael Clark and Cuevas, \{Nasmil J.Valera\} and Martin Darvas and Ding, \{Song Lin\} and Donald, \{Christine L.Mac\} and Rebecca Ferrer and Jessica Gloe and Junitta Guzman and Windy Ho and Keene, \{Lisa M.\} and Sarah Khawand and Kilgore, \{Mitchell D.\} and Amanda Keen and Mckaila Leytze and Zoe Maltzer and Naomi Martin and Rachel McCue and Delissa McMillen and Gonzalo Mena and Emma Meyerdierks and Meyers, \{Kelly P.\} and Mark Montine and Beagan Nguy and Nicholas Pe{\~n}a and Nolan, \{Amber L.\} and Nyhus, \{Julie K.\} and Olsen, \{Paul A.\} and Maiya Pacleb and Pagan, \{Chelsea M.\} and Trangthanh Pham and Christine Rimorin and Saldi, \{Giuseppe A.\} and Sarah Walling-Bell and Schantz, \{Aimee M.\} and Shapovalova, \{Nadiya V.\} and Sorensen, \{Staci A.\} and Sunkin, \{Susan M.\} and Michael Tieu and Amy Torkelson and Jack Waters and Wilson, \{Angela M.\} and Haynor, \{David R.\} and Gatto, \{Nicole M.\} and Suman Jayadev and Shubhabrata Mukherjee and Crane, \{Paul K.\} and Latimer, \{Caitlin S.\} and Levi, \{Boaz P.\} and Smith, \{Kimberly A.\} and Grabowski, \{Thomas J.\} and Larson, \{Eric B.\} and Close, \{Jennie L.\} and Hodge, \{Rebecca D.\} and Miller, \{Jeremy A.\} and Hawrylycz, \{Michael J.\} and Keene, \{C. Dirk\} and Lein, \{Ed S.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Alzheimer's Association. Alzheimer's \& Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2025",

month = dec,

day = "1",

doi = "10.1002/alz70861\_108223",

language = "English",

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T1 - An integrated, multiregional, and multimodal cell atlas of Alzheimer’s disease

AU - Travaglini, Kyle J.

AU - Ding, Yi

AU - Gabitto, Mariano I.

AU - Postupna, Nadia

AU - Mahoney, Joseph T.

AU - Kaplan, Eitan S.

AU - Goldy, Jeff

AU - Chakka, Anish Bhaswanth

AU - Tjaernberg, Andreas

AU - Kana, Omar

AU - Agrawal, Anamika

AU - Xiao, Ming

AU - Bajwa, Tejas S.

AU - Rachleff, Victoria M.

AU - Dee, Nick

AU - Melief, Erica J.

AU - Ariza, Jeanelle

AU - Long, Brian

AU - Gelfand, Emily

AU - Barlow, Samuel T.

AU - Bertagnolli, Darren

AU - Campos, Jazmin

AU - Campos, John S.

AU - Cardenas, Thanh

AU - Casper, Tamara

AU - Chakrabarty, Rushil

AU - Clark, Michael

AU - Cuevas, Nasmil J.Valera

AU - Darvas, Martin

AU - Ding, Song Lin

AU - Donald, Christine L.Mac

AU - Ferrer, Rebecca

AU - Gloe, Jessica

AU - Guzman, Junitta

AU - Ho, Windy

AU - Keene, Lisa M.

AU - Khawand, Sarah

AU - Kilgore, Mitchell D.

AU - Keen, Amanda

AU - Leytze, Mckaila

AU - Maltzer, Zoe

AU - Martin, Naomi

AU - McCue, Rachel

AU - McMillen, Delissa

AU - Mena, Gonzalo

AU - Meyerdierks, Emma

AU - Meyers, Kelly P.

AU - Montine, Mark

AU - Nguy, Beagan

AU - Peña, Nicholas

AU - Nolan, Amber L.

AU - Nyhus, Julie K.

AU - Olsen, Paul A.

AU - Pacleb, Maiya

AU - Pagan, Chelsea M.

AU - Pham, Trangthanh

AU - Rimorin, Christine

AU - Saldi, Giuseppe A.

AU - Walling-Bell, Sarah

AU - Schantz, Aimee M.

AU - Shapovalova, Nadiya V.

AU - Sorensen, Staci A.

AU - Sunkin, Susan M.

AU - Tieu, Michael

AU - Torkelson, Amy

AU - Waters, Jack

AU - Wilson, Angela M.

AU - Haynor, David R.

AU - Gatto, Nicole M.

AU - Jayadev, Suman

AU - Mukherjee, Shubhabrata

AU - Crane, Paul K.

AU - Latimer, Caitlin S.

AU - Levi, Boaz P.

AU - Smith, Kimberly A.

AU - Grabowski, Thomas J.

AU - Larson, Eric B.

AU - Close, Jennie L.

AU - Hodge, Rebecca D.

AU - Miller, Jeremy A.

AU - Hawrylycz, Michael J.

AU - Keene, C. Dirk

AU - Lein, Ed S.

PY - 2025/12/1

Y1 - 2025/12/1

UR - https://www.scopus.com/pages/publications/105025733179

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DO - 10.1002/alz70861_108223

M3 - Article

C2 - 41434486

AN - SCOPUS:105025733179

SN - 1552-5260

VL - 21

SP - e108223

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - S7

ER -

An integrated, multiregional, and multimodal cell atlas of Alzheimer’s disease

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