Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality

Lin Li; Xiaotian Qi; Weili Sun; Hisham Abdel-Azim; Siyue Lou; Hong Zhu; Nemani V. Prasadarao; Alice Zhou; Hiroyuki Shimada; Koichi Shudo; Yong Mi Kim; Sajad Khazal; Qiaojun He; David Warburton; Lingtao Wu

doi:10.15252/emmm.201606434

Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality

Lin Li
, Xiaotian Qi
, Weili Sun
, Hisham Abdel-Azim
, Siyue Lou
, Hong Zhu
, Nemani V. Prasadarao
, Alice Zhou
, Hiroyuki Shimada
, Koichi Shudo
, Yong Mi Kim
, Sajad Khazal
, Qiaojun He
, David Warburton
, Lingtao Wu

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1340-1359
Number of pages	20
Journal	EMBO Molecular Medicine
Volume	8
Issue number	11
DOIs	https://doi.org/10.15252/emmm.201606434
State	Published - Nov 1 2016
Externally published	Yes

ASJC Scopus Subject Areas

Molecular Medicine

Keywords

functional neutrophils
innate immunity
myeloid expansion
neutrophil bactericidal activity
neutrophil differentiation
Cell Differentiation/drug effects
Benzoates/administration & dosage
Neutropenia/chemically induced
Granulocyte Colony-Stimulating Factor/administration & dosage
Neutrophils/immunology
Animals
Bacteremia/immunology
Survival Analysis
Antineoplastic Agents/adverse effects
Mice
Cell Proliferation/drug effects
Immunologic Factors/administration & dosage
Tetrahydronaphthalenes/administration & dosage
Disease Models, Animal

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10.15252/emmm.201606434

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Cite this

Li, L., Qi, X., Sun, W., Abdel-Azim, H., Lou, S., Zhu, H., Prasadarao, N. V., Zhou, A., Shimada, H., Shudo, K., Kim, Y. M., Khazal, S., He, Q., Warburton, D., & Wu, L. (2016). Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality. EMBO Molecular Medicine, 8(11), 1340-1359. https://doi.org/10.15252/emmm.201606434

Li, L, Qi, X, Sun, W, Abdel-Azim, H, Lou, S, Zhu, H, Prasadarao, NV, Zhou, A, Shimada, H, Shudo, K, Kim, YM, Khazal, S, He, Q, Warburton, D & Wu, L 2016, 'Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality', EMBO Molecular Medicine, vol. 8, no. 11, pp. 1340-1359. https://doi.org/10.15252/emmm.201606434

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AU - Li, Lin

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AU - Abdel-Azim, Hisham

AU - Lou, Siyue

AU - Zhu, Hong

AU - Prasadarao, Nemani V.

AU - Zhou, Alice

AU - Shimada, Hiroyuki

AU - Shudo, Koichi

AU - Kim, Yong Mi

AU - Khazal, Sajad

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AU - Warburton, David

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