Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality

Lin Li; Xiaotian Qi; Weili Sun; Hisham Abdel-Azim; Siyue Lou; Hong Zhu; Nemani V. Prasadarao; Alice Zhou; Hiroyuki Shimada; Koichi Shudo; Yong Mi Kim; Sajad Khazal; Qiaojun He; David Warburton; Lingtao Wu

doi:10.15252/emmm.201606434

Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality

Lin Li, Xiaotian Qi, Weili Sun, Hisham Abdel-Azim, Siyue Lou, Hong Zhu, Nemani V. Prasadarao, Alice Zhou, Hiroyuki Shimada, Koichi Shudo, Yong Mi Kim, Sajad Khazal, Qiaojun He, David Warburton, Lingtao Wu

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1340-1359
Number of pages	20
Journal	EMBO Molecular Medicine
Volume	8
Issue number	11
DOIs	https://doi.org/10.15252/emmm.201606434
State	Published - Nov 1 2016
Externally published	Yes

ASJC Scopus Subject Areas

Molecular Medicine

Keywords

functional neutrophils
innate immunity
myeloid expansion
neutrophil bactericidal activity
neutrophil differentiation
Cell Differentiation/drug effects
Benzoates/administration & dosage
Neutropenia/chemically induced
Granulocyte Colony-Stimulating Factor/administration & dosage
Neutrophils/immunology
Animals
Bacteremia/immunology
Survival Analysis
Antineoplastic Agents/adverse effects
Mice
Cell Proliferation/drug effects
Immunologic Factors/administration & dosage
Tetrahydronaphthalenes/administration & dosage
Disease Models, Animal

Access to Document

10.15252/emmm.201606434

OpenUrl availability

Full text

Cite this

Li, L., Qi, X., Sun, W., Abdel-Azim, H., Lou, S., Zhu, H., Prasadarao, N. V., Zhou, A., Shimada, H., Shudo, K., Kim, Y. M., Khazal, S., He, Q., Warburton, D., & Wu, L. (2016). Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality. EMBO Molecular Medicine, 8(11), 1340-1359. https://doi.org/10.15252/emmm.201606434

Li, L, Qi, X, Sun, W, Abdel-Azim, H, Lou, S, Zhu, H, Prasadarao, NV, Zhou, A, Shimada, H, Shudo, K, Kim, YM, Khazal, S, He, Q, Warburton, D & Wu, L 2016, 'Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality', EMBO Molecular Medicine, vol. 8, no. 11, pp. 1340-1359. https://doi.org/10.15252/emmm.201606434

@article{5f67d9c5b4ff44a1909e968fb53cc46b,

title = "Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality",

keywords = "functional neutrophils, innate immunity, myeloid expansion, neutrophil bactericidal activity, neutrophil differentiation, Cell Differentiation/drug effects, Benzoates/administration & dosage, Neutropenia/chemically induced, Granulocyte Colony-Stimulating Factor/administration & dosage, Neutrophils/immunology, Animals, Bacteremia/immunology, Survival Analysis, Antineoplastic Agents/adverse effects, Mice, Cell Proliferation/drug effects, Immunologic Factors/administration & dosage, Tetrahydronaphthalenes/administration & dosage, Disease Models, Animal",

author = "Lin Li and Xiaotian Qi and Weili Sun and Hisham Abdel-Azim and Siyue Lou and Hong Zhu and Prasadarao, {Nemani V.} and Alice Zhou and Hiroyuki Shimada and Koichi Shudo and Kim, {Yong Mi} and Sajad Khazal and Qiaojun He and David Warburton and Lingtao Wu",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors. Published under the terms of the CC BY 4.0 license",

year = "2016",

month = nov,

day = "1",

doi = "10.15252/emmm.201606434",

language = "English",

volume = "8",

pages = "1340--1359",

journal = "EMBO Molecular Medicine",

issn = "1757-4676",

number = "11",

}

TY - JOUR

T1 - Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality

AU - Li, Lin

AU - Qi, Xiaotian

AU - Sun, Weili

AU - Abdel-Azim, Hisham

AU - Lou, Siyue

AU - Zhu, Hong

AU - Prasadarao, Nemani V.

AU - Zhou, Alice

AU - Shimada, Hiroyuki

AU - Shudo, Koichi

AU - Kim, Yong Mi

AU - Khazal, Sajad

AU - He, Qiaojun

AU - Warburton, David

AU - Wu, Lingtao

PY - 2016/11/1

Y1 - 2016/11/1

KW - functional neutrophils

KW - innate immunity

KW - myeloid expansion

KW - neutrophil bactericidal activity

KW - neutrophil differentiation

KW - Cell Differentiation/drug effects

KW - Benzoates/administration & dosage

KW - Neutropenia/chemically induced

KW - Granulocyte Colony-Stimulating Factor/administration & dosage

KW - Neutrophils/immunology

KW - Animals

KW - Bacteremia/immunology

KW - Survival Analysis

KW - Antineoplastic Agents/adverse effects

KW - Mice

KW - Cell Proliferation/drug effects

KW - Immunologic Factors/administration & dosage

KW - Tetrahydronaphthalenes/administration & dosage

KW - Disease Models, Animal

UR - http://www.scopus.com/inward/record.url?scp=84991406544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991406544&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/8dcded36-1cea-335a-871d-edc5880335a4/

U2 - 10.15252/emmm.201606434

DO - 10.15252/emmm.201606434

M3 - Article

C2 - 27737899

AN - SCOPUS:84991406544

SN - 1757-4676

VL - 8

SP - 1340

EP - 1359

JO - EMBO Molecular Medicine

JF - EMBO Molecular Medicine

IS - 11