Alkylation of cysteine 468 in stat3 defines a novel site for therapeutic development

Ralf Buettner; Renzo Corzano; Rumana Rashid; Jianping Lin; Maheswari Senthil; Michael Hedvat; Anne Schroeder; Allen Mao; Andreas Herrmann; John Yim; Hongzhi Li; Yate Ching Yuan; Kenichi Yakushijin; Fumiko Yakushijin; Nagarajan Vaidehi; Roger Moore; Gabriel Gugiu; Terry D. Lee; Richard Yip; Yuan Chen; Richard Jove; David Horne; John C. Williams

doi:10.1021/cb100253e

Alkylation of cysteine 468 in stat3 defines a novel site for therapeutic development

Ralf Buettner, Renzo Corzano, Rumana Rashid, Jianping Lin, Maheswari Senthil, Michael Hedvat, Anne Schroeder, Allen Mao, Andreas Herrmann, John Yim, Hongzhi Li, Yate Ching Yuan, Kenichi Yakushijin, Fumiko Yakushijin, Nagarajan Vaidehi, Roger Moore, Gabriel Gugiu, Terry D. Lee, Richard Yip, Yuan ChenRichard Jove, David Horne, John C. Williams

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	432-443
Number of pages	12
Journal	ACS Chemical Biology
Volume	6
Issue number	5
DOIs	https://doi.org/10.1021/cb100253e
State	Published - May 20 2011
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine

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Buettner, R., Corzano, R., Rashid, R., Lin, J., Senthil, M., Hedvat, M., Schroeder, A., Mao, A., Herrmann, A., Yim, J., Li, H., Yuan, Y. C., Yakushijin, K., Yakushijin, F., Vaidehi, N., Moore, R., Gugiu, G., Lee, T. D., Yip, R., ... Williams, J. C. (2011). Alkylation of cysteine 468 in stat3 defines a novel site for therapeutic development. ACS Chemical Biology, 6(5), 432-443. https://doi.org/10.1021/cb100253e

Buettner, R, Corzano, R, Rashid, R, Lin, J, Senthil, M, Hedvat, M, Schroeder, A, Mao, A, Herrmann, A, Yim, J, Li, H, Yuan, YC, Yakushijin, K, Yakushijin, F, Vaidehi, N, Moore, R, Gugiu, G, Lee, TD, Yip, R, Chen, Y, Jove, R, Horne, D & Williams, JC 2011, 'Alkylation of cysteine 468 in stat3 defines a novel site for therapeutic development', ACS Chemical Biology, vol. 6, no. 5, pp. 432-443. https://doi.org/10.1021/cb100253e

@article{84b659561640452589742e6c58a46ef4,

title = "Alkylation of cysteine 468 in stat3 defines a novel site for therapeutic development",

author = "Ralf Buettner and Renzo Corzano and Rumana Rashid and Jianping Lin and Maheswari Senthil and Michael Hedvat and Anne Schroeder and Allen Mao and Andreas Herrmann and John Yim and Hongzhi Li and Yuan, {Yate Ching} and Kenichi Yakushijin and Fumiko Yakushijin and Nagarajan Vaidehi and Roger Moore and Gabriel Gugiu and Lee, {Terry D.} and Richard Yip and Yuan Chen and Richard Jove and David Horne and Williams, {John C.}",

note = "Stat3 is a latent transcription factor that promotes cell survival and proliferation and is often constitutively active in multiple cancers. Inhibition of Stat3 signaling pathways suppresses cell survival signals and leads to apoptosis in cancer cells, suggesting direct inhibition of Stat3 function is a viable therapeutic approach.",

year = "2011",

month = may,

day = "20",

doi = "10.1021/cb100253e",

language = "English",

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AU - Buettner, Ralf

AU - Corzano, Renzo

AU - Rashid, Rumana

AU - Lin, Jianping

AU - Senthil, Maheswari

AU - Hedvat, Michael

AU - Schroeder, Anne

AU - Mao, Allen

AU - Herrmann, Andreas

AU - Yim, John

AU - Li, Hongzhi

AU - Yuan, Yate Ching

AU - Yakushijin, Kenichi

AU - Yakushijin, Fumiko

AU - Vaidehi, Nagarajan

AU - Moore, Roger

AU - Gugiu, Gabriel

AU - Lee, Terry D.

AU - Yip, Richard

AU - Chen, Yuan

AU - Jove, Richard

AU - Horne, David

AU - Williams, John C.

N1 - Stat3 is a latent transcription factor that promotes cell survival and proliferation and is often constitutively active in multiple cancers. Inhibition of Stat3 signaling pathways suppresses cell survival signals and leads to apoptosis in cancer cells, suggesting direct inhibition of Stat3 function is a viable therapeutic approach.

PY - 2011/5/20

Y1 - 2011/5/20

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U2 - 10.1021/cb100253e

DO - 10.1021/cb100253e

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JO - ACS Chemical Biology

JF - ACS Chemical Biology

IS - 5

ER -

Alkylation of cysteine 468 in stat3 defines a novel site for therapeutic development

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