TY - JOUR
T1 - Albuterol nebulized in heliox in the initial ED treatment of pediatric asthma
T2 - A blinded, randomized controlled trial
AU - Rivera, Michelle L.
AU - Kim, Tommy Y.
AU - Stewart, Gail M.
AU - Minasyan, Lilit
AU - Brown, Lance
N1 - OBJECTIVE: A prospective blinded, randomized controlled trial was undertaken to compare the initial response of albuterol nebulized in heliox or control in the treatment of moderately severe asthma in children presenting to a pediatric ED. METHODS: Patients were randomized to receive heliox (n = 20) or control (n = 21).
PY - 2006/1
Y1 - 2006/1
N2 - Objective: A prospective blinded, randomized controlled trial was undertaken to compare the initial response of albuterol nebulized in heliox or control in the treatment of moderately severe asthma in children presenting to a pediatric ED. Methods: Patients were randomized to receive heliox (n = 20) or control (n = 21). The primary outcome was to compare a modified dyspnea index score at 10 and 20 minutes after randomization. Secondary outcomes were to determine if heliox decreased admission rates or endotracheal intubation. Results: There was no statistically significant difference found at 10 or 20 minutes after randomization with heliox (P = .169 and P = .062, respectively). No statistical difference in admission rate was found, and no patients required endotracheal intubation in either group. Conclusions: Our results demonstrate that albuterol nebulized with heliox offered no clinical benefit over standard therapy in the initial treatment of moderately severe asthma in the ED.
AB - Objective: A prospective blinded, randomized controlled trial was undertaken to compare the initial response of albuterol nebulized in heliox or control in the treatment of moderately severe asthma in children presenting to a pediatric ED. Methods: Patients were randomized to receive heliox (n = 20) or control (n = 21). The primary outcome was to compare a modified dyspnea index score at 10 and 20 minutes after randomization. Secondary outcomes were to determine if heliox decreased admission rates or endotracheal intubation. Results: There was no statistically significant difference found at 10 or 20 minutes after randomization with heliox (P = .169 and P = .062, respectively). No statistical difference in admission rate was found, and no patients required endotracheal intubation in either group. Conclusions: Our results demonstrate that albuterol nebulized with heliox offered no clinical benefit over standard therapy in the initial treatment of moderately severe asthma in the ED.
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U2 - 10.1016/j.ajem.2005.06.007
DO - 10.1016/j.ajem.2005.06.007
M3 - Article
C2 - 16338507
SN - 0735-6757
VL - 24
SP - 38
EP - 42
JO - American Journal of Emergency Medicine
JF - American Journal of Emergency Medicine
IS - 1
ER -