TY - JOUR
T1 - Age-related loss of distortion product otoacoustic emissions in four mouse strains
AU - Jimenez, Ana M.
AU - Stagner, Barden B.
AU - Martin, Glen K.
AU - Lonsbury-Martin, Brenda L.
N1 - Funding Information:
Supported in part by the Public Health Service (DC00613, DC03114, GM16153) and the University of Miami’s Neuroscience Program and Chandler Chair Fund.
PY - 1999/12
Y1 - 1999/12
N2 - Changes in cochlear function in four inbred strains of mice, CBA/CaJ (CBA), C57BL/6J (C57), BALB/cByJ (BALB), and WB/ReJ (WB), previously used to study age-related hearing loss, were evaluated serially as a function of age with 2f1-f2 distortion-product otoacoustic emissions (DPOAEs). DPOAE levels in response to equilevel primary tones for geometric-mean (GM) frequencies from 5.6 to 48.5 kHz were recorded systematically as DP-grams and response/growth or input/output (I/O) functions at monthly intervals from about 2 to 15 months of age. Over the approximate 13-month measurement period, CBAs showed robust and unchanged DPOAEs for all tested frequencies, while BALBs, C57s, and WBs showed strain-specific, age-related decreases in DPOAEs that progressed systematically from the high to low frequencies. Specifically, for the youngest WBs at 2 months of age, no DPOAEs were recordable for GM frequencies ≥ 32 kHz, while C57s and BALBs reached the identical stage of cochlear dysfunction by 5 and 8 months, respectively. The differential decline in DPOAE activity shown for WB, C57, and BALB mice supports the notion that they represent unique animal models of age-related changes in cochlear function. In contrast, the unchanging DPOAEs for CBAs over the same time period indicate that this strain makes an effective control for normal cochlear function in the mouse, at least, up to 15 months of age.
AB - Changes in cochlear function in four inbred strains of mice, CBA/CaJ (CBA), C57BL/6J (C57), BALB/cByJ (BALB), and WB/ReJ (WB), previously used to study age-related hearing loss, were evaluated serially as a function of age with 2f1-f2 distortion-product otoacoustic emissions (DPOAEs). DPOAE levels in response to equilevel primary tones for geometric-mean (GM) frequencies from 5.6 to 48.5 kHz were recorded systematically as DP-grams and response/growth or input/output (I/O) functions at monthly intervals from about 2 to 15 months of age. Over the approximate 13-month measurement period, CBAs showed robust and unchanged DPOAEs for all tested frequencies, while BALBs, C57s, and WBs showed strain-specific, age-related decreases in DPOAEs that progressed systematically from the high to low frequencies. Specifically, for the youngest WBs at 2 months of age, no DPOAEs were recordable for GM frequencies ≥ 32 kHz, while C57s and BALBs reached the identical stage of cochlear dysfunction by 5 and 8 months, respectively. The differential decline in DPOAE activity shown for WB, C57, and BALB mice supports the notion that they represent unique animal models of age-related changes in cochlear function. In contrast, the unchanging DPOAEs for CBAs over the same time period indicate that this strain makes an effective control for normal cochlear function in the mouse, at least, up to 15 months of age.
KW - Aging
KW - Cochlea
KW - Distortion product otoacoustic emission
KW - Inbred mouse strain
UR - https://www.scopus.com/pages/publications/0032703896
UR - https://www.scopus.com/pages/publications/0032703896#tab=citedBy
U2 - 10.1016/S0378-5955(99)00154-9
DO - 10.1016/S0378-5955(99)00154-9
M3 - Article
C2 - 10575118
SN - 0378-5955
VL - 138
SP - 91
EP - 105
JO - Hearing Research
JF - Hearing Research
IS - 1-2
ER -