Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats

Ningbo Xu; Xifeng Li; Jun Weng; Chunhua Wei; Zhenyan He; Desislava Met Doycheva; Cameron Lenahan; Wenhui Tang; Jian Zhou; Yanchao Liu; Qiang Xu; Yahong Liu; Xuying He; Jiping Tang; John H. Zhang; Chuanzhi Duan

doi:10.3389/fimmu.2022.873382

Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats

Ningbo Xu, Xifeng Li, Jun Weng, Chunhua Wei, Zhenyan He, Desislava Met Doycheva, Cameron Lenahan, Wenhui Tang, Jian Zhou, Yanchao Liu, Qiang Xu, Yahong Liu, Xuying He, Jiping Tang, John H. Zhang, Chuanzhi Duan

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	873382
Journal	Frontiers in Immunology
Volume	13
DOIs	https://doi.org/10.3389/fimmu.2022.873382
State	Published - Jun 3 2022

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology

Keywords

GMH
adiponectin
hematoma resolution
microglial polarization
neuroinflammation
Animals, Newborn
Adiponectin/metabolism
Microglia/metabolism
PPAR gamma/metabolism
Signal Transduction
Rats
Adaptor Proteins, Signal Transducing/metabolism
Animals
Brain Injuries/drug therapy
Nerve Tissue Proteins/metabolism
Cerebral Hemorrhage/drug therapy
AMP-Activated Protein Kinases/metabolism
Carrier Proteins/metabolism

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Xu, N., Li, X., Weng, J., Wei, C., He, Z., Doycheva, D. M., Lenahan, C., Tang, W., Zhou, J., Liu, Y., Xu, Q., Liu, Y., He, X., Tang, J., Zhang, J. H., & Duan, C. (2022). Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats. Frontiers in Immunology, 13, Article 873382. https://doi.org/10.3389/fimmu.2022.873382

Xu, N, Li, X, Weng, J, Wei, C, He, Z, Doycheva, DM, Lenahan, C, Tang, W, Zhou, J, Liu, Y, Xu, Q, Liu, Y, He, X, Tang, J , Zhang, JH & Duan, C 2022, 'Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats', Frontiers in Immunology, vol. 13, 873382. https://doi.org/10.3389/fimmu.2022.873382

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title = "Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats",

keywords = "GMH, adiponectin, hematoma resolution, microglial polarization, neuroinflammation, Animals, Newborn, Adiponectin/metabolism, Microglia/metabolism, PPAR gamma/metabolism, Signal Transduction, Rats, Adaptor Proteins, Signal Transducing/metabolism, Animals, Brain Injuries/drug therapy, Nerve Tissue Proteins/metabolism, Cerebral Hemorrhage/drug therapy, AMP-Activated Protein Kinases/metabolism, Carrier Proteins/metabolism",

author = "Ningbo Xu and Xifeng Li and Jun Weng and Chunhua Wei and Zhenyan He and Doycheva, {Desislava Met} and Cameron Lenahan and Wenhui Tang and Jian Zhou and Yanchao Liu and Qiang Xu and Yahong Liu and Xuying He and Jiping Tang and Zhang, {John H.} and Chuanzhi Duan",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Xu, Li, Weng, Wei, He, Doycheva, Lenahan, Tang, Zhou, Liu, Xu, Liu, He, Tang, Zhang and Duan.",

year = "2022",

month = jun,

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AU - Li, Xifeng

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AU - Wei, Chunhua

AU - He, Zhenyan

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AU - Xu, Qiang

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AU - Zhang, John H.

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Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats

ASJC Scopus Subject Areas

Keywords

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