TY - JOUR
T1 - ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated with Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells
AU - Li, Fei
AU - Song, Rui
AU - Ao, Lihua
AU - Reece, T. Brett
AU - Cleveland, Joseph C.
AU - Dong, Nianguo
AU - Fullerton, David A.
AU - Meng, Xianzhong
N1 - Publisher Copyright:
© 2017 American Heart Association, Inc.
PY - 2017/7/1
Y1 - 2017/7/1
KW - actin
KW - aortic valve
KW - aortic valve stenosis
KW - extracellular matrix
KW - signal transduction
KW - Toll-Like Receptor 4/genetics
KW - ADAMTS5 Protein/deficiency
KW - Humans
KW - Middle Aged
KW - Male
KW - Case-Control Studies
KW - Transfection
KW - RNA Interference
KW - Myofibroblasts/enzymology
KW - Adult
KW - Cell Transdifferentiation
KW - Matrilin Proteins/metabolism
KW - Calcinosis/enzymology
KW - Actins/genetics
KW - Signal Transduction
KW - Cells, Cultured
KW - Toll-Like Receptor 2/genetics
KW - NFATC Transcription Factors/genetics
KW - Core Binding Factor Alpha 1 Subunit/metabolism
KW - Phenotype
KW - Aortic Valve Stenosis/enzymology
KW - Aortic Valve/enzymology
KW - Aged
KW - NF-kappa B/metabolism
KW - Alkaline Phosphatase/metabolism
KW - Osteogenesis
UR - https://www.scopus.com/pages/publications/85019748399
UR - https://www.scopus.com/pages/publications/85019748399#tab=citedBy
UR - https://www.mendeley.com/catalogue/ef754aee-6fd4-3f1d-80ca-51c4b470f97b/
U2 - 10.1161/ATVBAHA.117.309021
DO - 10.1161/ATVBAHA.117.309021
M3 - Article
C2 - 28546218
AN - SCOPUS:85019748399
SN - 1079-5642
VL - 37
SP - 1339
EP - 1351
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 7
ER -