Activation of TLR3 induces osteogenic responses in human aortic valve interstitial cells through the NF-κB and ERK1/2 pathways

  • Qiong Zhan
  • , Rui Song
  • , Qingchun Zeng
  • , Qingzhou Yao
  • , Lihua Ao
  • , Dingli Xu
  • , David A. Fullerton
  • , Xianzhong Meng

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)482-493
Number of pages12
JournalInternational Journal of Biological Sciences
Volume11
Issue number4
DOIs
StatePublished - Mar 20 2015
Externally publishedYes

ASJC Scopus Subject Areas

  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Keywords

  • Aortic valve interstitial cells
  • BMP-2
  • Calcification
  • TGF-β1
  • TLR3
  • Heart Valve Diseases/metabolism
  • Osteogenesis/physiology
  • Toll-Like Receptor 3/metabolism
  • Humans
  • Transforming Growth Factor beta1/metabolism
  • Cells, Cultured
  • Bicuspid Aortic Valve Disease
  • Heart Defects, Congenital/metabolism
  • Calcinosis/metabolism
  • Bone Morphogenetic Protein 2/metabolism
  • Aortic Valve/metabolism
  • MAP Kinase Signaling System/physiology
  • Toll-Like Receptor 4/metabolism
  • NF-kappa B/metabolism
  • Aortic Valve Stenosis/metabolism
  • Alkaline Phosphatase/metabolism

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