Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats

Shucai Xie; Xili Jiang; Desislava Met Doycheva; Hui Shi; Peng Jin; Ling Gao; Rui Liu; Jie Xiao; Xiao Hu; Jiping Tang; Lina Zhang; John H. Zhang

doi:10.1186/s12974-021-02289-7

Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats

Shucai Xie
, Xili Jiang
, Desislava Met Doycheva
, Hui Shi
, Peng Jin
, Ling Gao
, Rui Liu
, Jie Xiao
, Xiao Hu
, Jiping Tang
, Lina Zhang
, John H. Zhang

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	226
Journal	Journal of neuroinflammation
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12974-021-02289-7
State	Published - Oct 13 2021

ASJC Scopus Subject Areas

General Neuroscience
Immunology
Neurology
Cellular and Molecular Neuroscience

Keywords

GPR39
Hypoxic–ischemic encephalopathy
Microglia
Neuroinflammation
Nrf2
PGC-1α
SIRT1
TC-G 1008
Animals, Newborn
Sirtuin 1/biosynthesis
Inflammation/metabolism
NF-E2-Related Factor 2/biosynthesis
Rats
Rats, Sprague-Dawley
Signal Transduction/drug effects
Pyrimidines/pharmacology
Receptors, G-Protein-Coupled/agonists
Animals
Sulfonamides/pharmacology
Hypoxia-Ischemia, Brain/metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/biosynthesis

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10.1186/s12974-021-02289-7

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Xie, S., Jiang, X., Doycheva, D. M., Shi, H., Jin, P., Gao, L., Liu, R., Xiao, J., Hu, X., Tang, J., Zhang, L., & Zhang, J. H. (2021). Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats. Journal of neuroinflammation, 18(1), Article 226. https://doi.org/10.1186/s12974-021-02289-7

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author = "Shucai Xie and Xili Jiang and Doycheva, \{Desislava Met\} and Hui Shi and Peng Jin and Ling Gao and Rui Liu and Jie Xiao and Xiao Hu and Jiping Tang and Lina Zhang and Zhang, \{John H.\}",

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year = "2021",

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doi = "10.1186/s12974-021-02289-7",

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T1 - Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats

AU - Xie, Shucai

AU - Jiang, Xili

AU - Doycheva, Desislava Met

AU - Shi, Hui

AU - Jin, Peng

AU - Gao, Ling

AU - Liu, Rui

AU - Xiao, Jie

AU - Hu, Xiao

AU - Tang, Jiping

AU - Zhang, Lina

AU - Zhang, John H.

PY - 2021/10/13

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KW - Hypoxic–ischemic encephalopathy

KW - Microglia

KW - Neuroinflammation

KW - Nrf2

KW - PGC-1α

KW - SIRT1

KW - TC-G 1008

KW - Animals, Newborn

KW - Sirtuin 1/biosynthesis

KW - Inflammation/metabolism

KW - NF-E2-Related Factor 2/biosynthesis

KW - Rats

KW - Rats, Sprague-Dawley

KW - Signal Transduction/drug effects

KW - Pyrimidines/pharmacology

KW - Receptors, G-Protein-Coupled/agonists

KW - Animals

KW - Sulfonamides/pharmacology

KW - Hypoxia-Ischemia, Brain/metabolism

KW - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/biosynthesis

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ER -

Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats

ASJC Scopus Subject Areas

Keywords

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