TY - JOUR
T1 - ACE DD genotype associated with the female Chronic Kidney Disease patients of Tamilnadu population
AU - Nagamani, Selvaraman
AU - Shanmuga Perumal, M.
AU - Leela Shanmuga Perumal, R.
AU - Kesavan, Chandrasekhar
AU - Muthusamy, Kartikeyan
N1 - Publisher Copyright:
© 2014 .
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background: The Renin-Angiotensin System (RAS) is an important regulator for blood pressure and kidney disease. The level of vaso active peptide Angiotensin-II is mainly determined by the RAS enzyme angiotensin converting enzyme-1 (ACE-1). Aim: To investigate the association of ACE I/D polymorphism and Chronic Kidney Disease (CKD) in south India. Methods: In the present study, we have collected CKD patients (. n=. 147) and control subjects (. n=. 211) from Tamilnadu. Genotyping was carried out by polymerase chain reaction (PCR) on the basis of allele specific primers. Results: The DD genotype is associated with the female population (OR-CI. =. 2.40 (1.05-5.51), p=. 0.04) as compared to the male population (OR-CI. =. 0.75 (0.37-1.51), p=. 0.42). Further, we found the over representation of "I" - allele (homozygous II and heterozygous ID) in unaffected males [OR (CI) - 0.58 (0.32-1.04), p=. 0.07] which suggests its protective role in male population. Conclusion: The DD genotype of ACE is associated with CKD in south India.
AB - Background: The Renin-Angiotensin System (RAS) is an important regulator for blood pressure and kidney disease. The level of vaso active peptide Angiotensin-II is mainly determined by the RAS enzyme angiotensin converting enzyme-1 (ACE-1). Aim: To investigate the association of ACE I/D polymorphism and Chronic Kidney Disease (CKD) in south India. Methods: In the present study, we have collected CKD patients (. n=. 147) and control subjects (. n=. 211) from Tamilnadu. Genotyping was carried out by polymerase chain reaction (PCR) on the basis of allele specific primers. Results: The DD genotype is associated with the female population (OR-CI. =. 2.40 (1.05-5.51), p=. 0.04) as compared to the male population (OR-CI. =. 0.75 (0.37-1.51), p=. 0.42). Further, we found the over representation of "I" - allele (homozygous II and heterozygous ID) in unaffected males [OR (CI) - 0.58 (0.32-1.04), p=. 0.07] which suggests its protective role in male population. Conclusion: The DD genotype of ACE is associated with CKD in south India.
KW - ACE I/D polymorphism
KW - Case control study
KW - Chronic kidney disease
KW - HWE
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U2 - 10.1016/j.ejmhg.2014.10.002
DO - 10.1016/j.ejmhg.2014.10.002
M3 - Article
SN - 1110-8630
VL - 16
SP - 29
EP - 33
JO - Egyptian Journal of Medical Human Genetics
JF - Egyptian Journal of Medical Human Genetics
IS - 1
ER -