Abstract 871: Regulation of CDC25a expression by the ikaros and casein kinase II (CK2) in T-cell acute lymphoblastic leukemia (T-ALL)

Soumya C. Iyer; Shriya Kane; Chandrika Gowda; Chunhua Song; Yali Ding; Jon Payne; Pavan Kumar Dhanyam Raju; Bihua Tan; Mary McGrath; Yevgeniya Bamme; Mario Solimon; Nathalia Moreno Cury; Dhimant Desai; Arati Sharma; Kimberly J. Payne; Sinisa Dovat

doi:10.1158/1538-7445.SABCS18-871

Abstract 871: Regulation of CDC25a expression by the ikaros and casein kinase II (CK2) in T-cell acute lymphoblastic leukemia (T-ALL)

Soumya C. Iyer
, Shriya Kane
, Chandrika Gowda
, Chunhua Song
, Yali Ding
, Jon Payne
, Pavan Kumar Dhanyam Raju
, Bihua Tan
, Mary McGrath
, Yevgeniya Bamme
, Mario Solimon
, Nathalia Moreno Cury
, Dhimant Desai
, Arati Sharma
, Kimberly J. Payne
, Sinisa Dovat

Loma Linda University

Research output: Contribution to conference › Poster › peer-review

Original language	American English
Pages	871
Number of pages	1
DOIs	https://doi.org/10.1158/1538-7445.SABCS18-871
State	Published - Jul 1 2019

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Molecular Biology

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Iyer, S. C., Kane, S., Gowda, C., Song, C., Ding, Y., Payne, J., Raju, P. K. D., Tan, B., McGrath, M., Bamme, Y., Solimon, M., Cury, N. M., Desai, D., Sharma, A., Payne, K. J., & Dovat, S. (2019). Abstract 871: Regulation of CDC25a expression by the ikaros and casein kinase II (CK2) in T-cell acute lymphoblastic leukemia (T-ALL). 871. https://doi.org/10.1158/1538-7445.SABCS18-871

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title = "Abstract 871: Regulation of CDC25a expression by the ikaros and casein kinase II (CK2) in T-cell acute lymphoblastic leukemia (T-ALL)",

author = "Iyer, \{Soumya C.\} and Shriya Kane and Chandrika Gowda and Chunhua Song and Yali Ding and Jon Payne and Raju, \{Pavan Kumar Dhanyam\} and Bihua Tan and Mary McGrath and Yevgeniya Bamme and Mario Solimon and Cury, \{Nathalia Moreno\} and Dhimant Desai and Arati Sharma and Payne, \{Kimberly J.\} and Sinisa Dovat",

note = "Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA CDC25A is a member of the CDC25 family of phosphatases that plays a major role in cell cycle progression. Here, we present evidence that expression of CDC25a in T-ALL is regulated at the transcriptional level by oncogenic Casein Kinase II (CK2) via direct phosphorylation of Ikaros, a transcription factor and tumor suppressor protein.",

year = "2019",

month = jul,

day = "1",

doi = "10.1158/1538-7445.SABCS18-871",

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TY - CONF

T1 - Abstract 871: Regulation of CDC25a expression by the ikaros and casein kinase II (CK2) in T-cell acute lymphoblastic leukemia (T-ALL)

AU - Iyer, Soumya C.

AU - Kane, Shriya

AU - Gowda, Chandrika

AU - Song, Chunhua

AU - Ding, Yali

AU - Payne, Jon

AU - Raju, Pavan Kumar Dhanyam

AU - Tan, Bihua

AU - McGrath, Mary

AU - Bamme, Yevgeniya

AU - Solimon, Mario

AU - Cury, Nathalia Moreno

AU - Desai, Dhimant

AU - Sharma, Arati

AU - Payne, Kimberly J.

AU - Dovat, Sinisa

N1 - Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA CDC25A is a member of the CDC25 family of phosphatases that plays a major role in cell cycle progression. Here, we present evidence that expression of CDC25a in T-ALL is regulated at the transcriptional level by oncogenic Casein Kinase II (CK2) via direct phosphorylation of Ikaros, a transcription factor and tumor suppressor protein.

PY - 2019/7/1

Y1 - 2019/7/1

UR - https://cancerres.aacrjournals.org/content/79/13_Supplement/871

U2 - 10.1158/1538-7445.SABCS18-871

DO - 10.1158/1538-7445.SABCS18-871

M3 - Poster

SP - 871

ER -

Abstract 871: Regulation of CDC25a expression by the ikaros and casein kinase II (CK2) in T-cell acute lymphoblastic leukemia (T-ALL)

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