Abstract 286: Synergistic efficacy of CK2 inhibitor with common chemotherapy drugs by restoring Ikaros function in high-risk ALL

chunhua song; Zheng Ge; Chandrika Gowda; Yali Ding; Jonathon Payne; Bihua Tan; Nathalia M. Cury; Elanora Dovat; Zhijun Zhao; Xiaoguang Lyu; Mary McGrath; Dhimant Desai; Soumya lyer; Pavan K. DhanyamRaju; Kimberly J. Payne; Sinisa Dovat

doi:10.1158/1538-7445.SABCS18-286

Abstract 286: Synergistic efficacy of CK2 inhibitor with common chemotherapy drugs by restoring Ikaros function in high-risk ALL

chunhua song
, Zheng Ge
, Chandrika Gowda
, Yali Ding
, Jonathon Payne
, Bihua Tan
, Nathalia M. Cury
, Elanora Dovat
, Zhijun Zhao
, Xiaoguang Lyu
, Mary McGrath
, Dhimant Desai
, Soumya lyer
, Pavan K. DhanyamRaju
, Kimberly J. Payne
, Sinisa Dovat

Loma Linda University

Research output: Contribution to conference › Poster › peer-review

Original language	American English
Pages	286
Number of pages	1
DOIs	https://doi.org/10.1158/1538-7445.SABCS18-286
State	Published - Jul 1 2019

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Oncology
Internal Medicine
Medicine and Health Sciences

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song, C., Ge, Z., Gowda, C., Ding, Y., Payne, J., Tan, B., Cury, N. M., Dovat, E., Zhao, Z., Lyu, X., McGrath, M., Desai, D., lyer, S., DhanyamRaju, P. K., Payne, K. J., & Dovat, S. (2019). Abstract 286: Synergistic efficacy of CK2 inhibitor with common chemotherapy drugs by restoring Ikaros function in high-risk ALL. 286. https://doi.org/10.1158/1538-7445.SABCS18-286

@conference{464e674bde7142509415c0d7b1004ba3,

title = "Abstract 286: Synergistic efficacy of CK2 inhibitor with common chemotherapy drugs by restoring Ikaros function in high-risk ALL",

author = "chunhua song and Zheng Ge and Chandrika Gowda and Yali Ding and Jonathon Payne and Bihua Tan and Cury, \{Nathalia M.\} and Elanora Dovat and Zhijun Zhao and Xiaoguang Lyu and Mary McGrath and Dhimant Desai and Soumya lyer and DhanyamRaju, \{Pavan K.\} and Payne, \{Kimberly J.\} and Sinisa Dovat",

note = "Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA Objective: IKZF1 gene-coding protein, Ikaros functions as a leukemia suppressor. Casein Kinase II activity is overexpressed in acute lymphoblastic leukemia (ALL) and CK2-mediated-dysfunction of Ikaros is one of the key reason for high-risk ALL and CK2 inhibitor -CX4945 treatment shows high therapeutic efficacy on high-risk ALL.",

year = "2019",

month = jul,

day = "1",

doi = "10.1158/1538-7445.SABCS18-286",

language = "American English",

pages = "286",

}

TY - CONF

T1 - Abstract 286: Synergistic efficacy of CK2 inhibitor with common chemotherapy drugs by restoring Ikaros function in high-risk ALL

AU - song, chunhua

AU - Ge, Zheng

AU - Gowda, Chandrika

AU - Ding, Yali

AU - Payne, Jonathon

AU - Tan, Bihua

AU - Cury, Nathalia M.

AU - Dovat, Elanora

AU - Zhao, Zhijun

AU - Lyu, Xiaoguang

AU - McGrath, Mary

AU - Desai, Dhimant

AU - lyer, Soumya

AU - DhanyamRaju, Pavan K.

AU - Payne, Kimberly J.

AU - Dovat, Sinisa

N1 - Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA Objective: IKZF1 gene-coding protein, Ikaros functions as a leukemia suppressor. Casein Kinase II activity is overexpressed in acute lymphoblastic leukemia (ALL) and CK2-mediated-dysfunction of Ikaros is one of the key reason for high-risk ALL and CK2 inhibitor -CX4945 treatment shows high therapeutic efficacy on high-risk ALL.

PY - 2019/7/1

Y1 - 2019/7/1

UR - https://cancerres.aacrjournals.org/content/79/13_Supplement/286

U2 - 10.1158/1538-7445.SABCS18-286

DO - 10.1158/1538-7445.SABCS18-286

M3 - Poster

SP - 286

ER -

Abstract 286: Synergistic efficacy of CK2 inhibitor with common chemotherapy drugs by restoring Ikaros function in high-risk ALL

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