A small molecular inhibitor of LRRK1 identified by homology modeling and virtual screening suppresses osteoclast function, but not osteoclast differentiation, in vitro

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)3250-3261
Number of pages12
JournalAging
Volume11
Issue number10
DOIs
StatePublished - May 1 2019

ASJC Scopus Subject Areas

  • Aging
  • Cell Biology

Keywords

  • Bone formation
  • Bone resorption
  • Kinase inhibitor
  • LRRK1
  • Osteoclast
  • Bone Resorption/drug therapy
  • Cell Differentiation/drug effects
  • Osteoporosis/drug therapy
  • Mice, Inbred C57BL
  • Osteoclasts/drug effects
  • Bone Marrow Cells/drug effects
  • Animals
  • Molecular Docking Simulation
  • Drug Evaluation, Preclinical
  • Protein Serine-Threonine Kinases/antagonists & inhibitors

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