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A Potential Role for the Amyloid Precursor Protein in the Regulation of Interferon Signaling, Cholesterol Homeostasis, and Tau Phosphorylation in Niemann–Pick Disease Type C

  • Kayla L. Sanchez
  • , Samuel D. Shin
  • , Naren P. Rajagopal
  • , Jacob B. White
  • , Antonio Currais
  • , David Soriano-Castell
  • , Pamela Maher
  • , Salvador Soriano

Research output: Contribution to journal › Article › peer-review

Original languageEnglish
Article number1066
JournalGenes
Volume15
Issue number8
DOIs
StatePublished - Aug 2024

ASJC Scopus Subject Areas

  • Genetics
  • Genetics(clinical)

Keywords

  • Amyloid Precursor Protein
  • Niemann-Pick disease type C
  • neurodegeneration
  • tau Proteins/metabolism
  • Phosphorylation
  • Signal Transduction
  • Cerebral Cortex/metabolism
  • Cholesterol/metabolism
  • Niemann-Pick C1 Protein
  • Homeostasis
  • Mice, Knockout
  • Cerebellum/metabolism
  • Animals
  • Amyloid beta-Protein Precursor/genetics
  • Mice
  • Niemann-Pick Disease, Type C/metabolism
  • Interferons/metabolism
  • Disease Models, Animal

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