A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

Ilana Chefetz; Edward Grimley; Kun Yang; Linda Hong; Ekaterina V. Vinogradova; Radu Suciu; Ilya Kovalenko; David Karnak; Cynthia A. Morgan; Mikhail Chtcherbinine; Cameron Buchman; Brandt Huddle; Scott Barraza; Meredith Morgan; Kara A. Bernstein; Euisik Yoon; David B. Lombard; Andrea Bild; Geeta Mehta; Iris Romero; Chun Yi Chiang; Charles Landen; Benjamin Cravatt; Thomas D. Hurley; Scott D. Larsen; Ronald J. Buckanovich

doi:10.1016/j.celrep.2019.02.032

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

Ilana Chefetz, Edward Grimley, Kun Yang, Linda Hong, Ekaterina V. Vinogradova, Radu Suciu, Ilya Kovalenko, David Karnak, Cynthia A. Morgan, Mikhail Chtcherbinine, Cameron Buchman, Brandt Huddle, Scott Barraza, Meredith Morgan, Kara A. Bernstein, Euisik Yoon, David B. Lombard, Andrea Bild, Geeta Mehta, Iris RomeroChun Yi Chiang, Charles Landen, Benjamin Cravatt, Thomas D. Hurley, Scott D. Larsen, Ronald J. Buckanovich

Gynecology and Obstetrics

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	3061-3075.e6
Journal	Cell Reports
Volume	26
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2019.02.032
State	Published - Mar 12 2019

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

Keywords

ALDH
CD133
CSC
cell death
necroptosis
ovarian cancer
resistance

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Chefetz, I., Grimley, E., Yang, K., Hong, L., Vinogradova, E. V., Suciu, R., Kovalenko, I., Karnak, D., Morgan, C. A., Chtcherbinine, M., Buchman, C., Huddle, B., Barraza, S., Morgan, M., Bernstein, K. A., Yoon, E., Lombard, D. B., Bild, A., Mehta, G., ... Buckanovich, R. J. (2019). A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Reports, 26(11), 3061-3075.e6. https://doi.org/10.1016/j.celrep.2019.02.032

Chefetz, I, Grimley, E, Yang, K, Hong, L, Vinogradova, EV, Suciu, R, Kovalenko, I, Karnak, D, Morgan, CA, Chtcherbinine, M, Buchman, C, Huddle, B, Barraza, S, Morgan, M, Bernstein, KA, Yoon, E, Lombard, DB, Bild, A, Mehta, G, Romero, I, Chiang, CY, Landen, C, Cravatt, B, Hurley, TD, Larsen, SD & Buckanovich, RJ 2019, 'A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells', Cell Reports, vol. 26, no. 11, pp. 3061-3075.e6. https://doi.org/10.1016/j.celrep.2019.02.032

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title = "A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells",

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author = "Ilana Chefetz and Edward Grimley and Kun Yang and Linda Hong and Vinogradova, {Ekaterina V.} and Radu Suciu and Ilya Kovalenko and David Karnak and Morgan, {Cynthia A.} and Mikhail Chtcherbinine and Cameron Buchman and Brandt Huddle and Scott Barraza and Meredith Morgan and Bernstein, {Kara A.} and Euisik Yoon and Lombard, {David B.} and Andrea Bild and Geeta Mehta and Iris Romero and Chiang, {Chun Yi} and Charles Landen and Benjamin Cravatt and Hurley, {Thomas D.} and Larsen, {Scott D.} and Buckanovich, {Ronald J.}",

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AU - Chefetz, Ilana

AU - Grimley, Edward

AU - Yang, Kun

AU - Hong, Linda

AU - Vinogradova, Ekaterina V.

AU - Suciu, Radu

AU - Kovalenko, Ilya

AU - Karnak, David

AU - Morgan, Cynthia A.

AU - Chtcherbinine, Mikhail

AU - Buchman, Cameron

AU - Huddle, Brandt

AU - Barraza, Scott

AU - Morgan, Meredith

AU - Bernstein, Kara A.

AU - Yoon, Euisik

AU - Lombard, David B.

AU - Bild, Andrea

AU - Mehta, Geeta

AU - Romero, Iris

AU - Chiang, Chun Yi

AU - Landen, Charles

AU - Cravatt, Benjamin

AU - Hurley, Thomas D.

AU - Larsen, Scott D.

AU - Buckanovich, Ronald J.

PY - 2019/3/12

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KW - ALDH

KW - CD133

KW - CSC

KW - cell death

KW - necroptosis

KW - ovarian cancer

KW - resistance

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A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

ASJC Scopus Subject Areas

Keywords

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