A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals

Christoph Schaniel; Priyanka Dhanan; Bin Hu; Yuguang Xiong; Teeya Raghunandan; David M. Gonzalez; Rafael Dariolli; Sunita L. D'Souza; Arjun S. Yadaw; Jens Hansen; Gomathi Jayaraman; Bino Mathew; Moara Machado; Seth I. Berger; Joseph Tripodi; Vesna Najfeld; Jalaj Garg; Marc Miller; Colleen S. Surlyn; Katherine C. Michelis; Neelima C. Tangirala; Himali Weerahandi; David C. Thomas; Kristin G. Beaumont; Robert Sebra; Milind Mahajan; Eric Schadt; Dusica Vidovic; Stephan C. Schürer; Joseph Goldfarb; Evren U. Azeloglu; Marc R. Birtwistle; Eric A. Sobie; Jason C. Kovacic; Nicole C. Dubois; Ravi Iyengar

doi:10.1016/j.stemcr.2021.10.005

A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals

Christoph Schaniel
, Priyanka Dhanan
, Bin Hu
, Yuguang Xiong
, Teeya Raghunandan
, David M. Gonzalez
, Rafael Dariolli
, Sunita L. D'Souza
, Arjun S. Yadaw
, Jens Hansen
, Gomathi Jayaraman
, Bino Mathew
, Moara Machado
, Seth I. Berger
, Joseph Tripodi
, Vesna Najfeld
, Jalaj Garg
, Marc Miller
, Colleen S. Surlyn
, Katherine C. Michelis

Neelima C. Tangirala, Himali Weerahandi, David C. Thomas, Kristin G. Beaumont, Robert Sebra, Milind Mahajan, Eric Schadt, Dusica Vidovic, Stephan C. Schürer, Joseph Goldfarb, Evren U. Azeloglu, Marc R. Birtwistle, Eric A. Sobie, Jason C. Kovacic, Nicole C. Dubois, Ravi Iyengar

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	3036-3049
Number of pages	14
Journal	Stem Cell Reports
Volume	16
Issue number	12
DOIs	https://doi.org/10.1016/j.stemcr.2021.10.005
State	Published - Dec 14 2021

ASJC Scopus Subject Areas

Biochemistry
Genetics
Developmental Biology
Cell Biology

Keywords

age- and sex-independent gene signature
cardiomyocytes
clinically well-characterized healthy subjects
genetic variants of mild common disease phenotypes or more severe disease with incomplete penetrance
induced pluripotent stem cells
racially/ethnically diverse
similar physiology and transcriptomes
whole-genome sequencing
Humans
Middle Aged
Male
Gene Expression Profiling
Heart Atria/cytology
Genetic Variation
Young Adult
Adult
Female
Cell Differentiation
Clone Cells
Calcium Signaling
Myocytes, Cardiac/cytology
Cell Line
Genetic Predisposition to Disease
Health
Risk Factors
Gene Expression Regulation
Heart Ventricles/cytology
Induced Pluripotent Stem Cells/cytology
Ethnicity

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10.1016/j.stemcr.2021.10.005

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Schaniel, C., Dhanan, P., Hu, B., Xiong, Y., Raghunandan, T., Gonzalez, D. M., Dariolli, R., D'Souza, S. L., Yadaw, A. S., Hansen, J., Jayaraman, G., Mathew, B., Machado, M., Berger, S. I., Tripodi, J., Najfeld, V., Garg, J., Miller, M., Surlyn, C. S., ... Iyengar, R. (2021). A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals. Stem Cell Reports, 16(12), 3036-3049. https://doi.org/10.1016/j.stemcr.2021.10.005

Schaniel, C, Dhanan, P, Hu, B, Xiong, Y, Raghunandan, T, Gonzalez, DM, Dariolli, R, D'Souza, SL, Yadaw, AS, Hansen, J, Jayaraman, G, Mathew, B, Machado, M, Berger, SI, Tripodi, J, Najfeld, V, Garg, J, Miller, M, Surlyn, CS, Michelis, KC, Tangirala, NC, Weerahandi, H, Thomas, DC, Beaumont, KG, Sebra, R, Mahajan, M, Schadt, E, Vidovic, D, Schürer, SC, Goldfarb, J, Azeloglu, EU, Birtwistle, MR, Sobie, EA, Kovacic, JC, Dubois, NC & Iyengar, R 2021, 'A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals', Stem Cell Reports, vol. 16, no. 12, pp. 3036-3049. https://doi.org/10.1016/j.stemcr.2021.10.005

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AU - Schadt, Eric

AU - Vidovic, Dusica

AU - Schürer, Stephan C.

AU - Goldfarb, Joseph

AU - Azeloglu, Evren U.

AU - Birtwistle, Marc R.

AU - Sobie, Eric A.

AU - Kovacic, Jason C.

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KW - Health

KW - Risk Factors

KW - Gene Expression Regulation

KW - Heart Ventricles/cytology

KW - Induced Pluripotent Stem Cells/cytology

KW - Ethnicity

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A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals

ASJC Scopus Subject Areas

Keywords

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