@article{f052bd353d954b85996ce5cf849e1d27,
title = "A high spatial resolution in vivo 1H magnetic resonance spectroscopic imaging technique for the human breast at 3 T",
keywords = "Breast cancer, Choline, Creatine, High spatial resolution 1H MRSI, Taurine, Protons, Humans, Magnetic Resonance Imaging/methods, Breast/metabolism, Feasibility Studies, Choline/metabolism, Magnetic Resonance Spectroscopy/methods, Female, Breast Neoplasms/metabolism",
author = "Jiani Hu and Wenzheng Feng and Jia Hua and Quan Jiang and Yang Xuan and Tao Li and Haacke, \{E. Mark\}",
note = "Funding Information: This work was supported in part by The Susan G. Komen Breast Cancer Foundation (Grant No. IMG0402881) and NIH (Grant No. CA118569-01A1). The authors thank Dr. Renate Soulen for her comments and discussion on the study. FIG. 1. Typical quality high spatial resolution 1H spectra of the breast in a patient with histologically proven invasive lobular carcinoma demonstrating 1H metabolite heterogeneity. (a) 1H spectrum from a tumor area (the voxel in (c)). (b) 1H spectrum from the same area as (a) but displayed in different scale and spectral range. (c) Coronal MRI guiding the MRSI. (d)–(f) are spectra from three different MRI-lesion areas of the same patient. (g) is a spectrum from a normal appearing area. (h) is a color-coded Cho image overlaid on the corresponding MRI. FIG. 2. Advantage of 1H MRSI in localizing small abnormal metabolite areas in a patient undergoing neoadjuvant chemotherapy for histologically proven invasive ductal carcinoma. (a) and (b) are spectra from two different MRI lesion areas. (c) and (d) are spectra from two nearby normal appearing areas of the same patient. The patient did not respond well to the chemotherapy. FIG. 3. Spectra extracted from a 3D MRSI with a 62 Hz WWHH over the whole volume of interest in a patient with two disparate lesions in the same breast. (a) Spectrum from the control region. (b) Spectrum from one tumor region. (c) A color-coded Cho image overlaid on the corresponding MRI slice covering the tumor lesion for spectrum 3b. (d) A color-coded Cho image overlaid on the corresponding MRI covering the another lesion in the same breast. Other parameters are as follows: TE = 30 ms , TR = 2000 ms , average = 2 , matrix = 12 × 12 × 8 , and acquisition time = 11 : 43 min . ",
year = "2009",
month = nov,
doi = "10.1118/1.3213087",
language = "English",
volume = "36",
pages = "4870--4877",
journal = "Medical Physics",
issn = "0094-2405",
number = "11",
}