| Original language | English |
|---|---|
| Pages (from-to) | 4870-4877 |
| Number of pages | 8 |
| Journal | Medical Physics |
| Volume | 36 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2009 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- Biophysics
- Radiology Nuclear Medicine and imaging
Keywords
- Breast cancer
- Choline
- Creatine
- High spatial resolution 1H MRSI
- Taurine
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In: Medical Physics, Vol. 36, No. 11, 2009, p. 4870-4877.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - A high spatial resolution in vivo 1H magnetic resonance spectroscopic imaging technique for the human breast at 3 T
AU - Hu, Jiani
AU - Feng, Wenzheng
AU - Hua, Jia
AU - Jiang, Quan
AU - Xuan, Yang
AU - Li, Tao
AU - Haacke, E. Mark
N1 - Funding Information: This work was supported in part by The Susan G. Komen Breast Cancer Foundation (Grant No. IMG0402881) and NIH (Grant No. CA118569-01A1). The authors thank Dr. Renate Soulen for her comments and discussion on the study. FIG. 1. Typical quality high spatial resolution 1H spectra of the breast in a patient with histologically proven invasive lobular carcinoma demonstrating 1H metabolite heterogeneity. (a) 1H spectrum from a tumor area (the voxel in (c)). (b) 1H spectrum from the same area as (a) but displayed in different scale and spectral range. (c) Coronal MRI guiding the MRSI. (d)–(f) are spectra from three different MRI-lesion areas of the same patient. (g) is a spectrum from a normal appearing area. (h) is a color-coded Cho image overlaid on the corresponding MRI. FIG. 2. Advantage of 1H MRSI in localizing small abnormal metabolite areas in a patient undergoing neoadjuvant chemotherapy for histologically proven invasive ductal carcinoma. (a) and (b) are spectra from two different MRI lesion areas. (c) and (d) are spectra from two nearby normal appearing areas of the same patient. The patient did not respond well to the chemotherapy. FIG. 3. Spectra extracted from a 3D MRSI with a 62 Hz WWHH over the whole volume of interest in a patient with two disparate lesions in the same breast. (a) Spectrum from the control region. (b) Spectrum from one tumor region. (c) A color-coded Cho image overlaid on the corresponding MRI slice covering the tumor lesion for spectrum 3b. (d) A color-coded Cho image overlaid on the corresponding MRI covering the another lesion in the same breast. Other parameters are as follows: TE = 30 ms , TR = 2000 ms , average = 2 , matrix = 12 × 12 × 8 , and acquisition time = 11 : 43 min .
PY - 2009
Y1 - 2009
KW - Breast cancer
KW - Choline
KW - Creatine
KW - High spatial resolution 1H MRSI
KW - Taurine
UR - http://www.scopus.com/inward/record.url?scp=70350743454&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350743454&partnerID=8YFLogxK
U2 - 10.1118/1.3213087
DO - 10.1118/1.3213087
M3 - Article
C2 - 19994494
AN - SCOPUS:70350743454
SN - 0094-2405
VL - 36
SP - 4870
EP - 4877
JO - Medical Physics
JF - Medical Physics
IS - 11
ER -