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A functional polymorphism of the Gαq (GNAQ) gene is associated with accelerated mortality in African-American heart failure

  • Stephen B. Liggett
  • , Reagan J. Kelly
  • , Rohan R. Parekh
  • , Scot J. Matkovich
  • , Bonnie J. Benner
  • , Harvey S. Hahn
  • , Faisal M. Syed
  • , Anita S. Galvez
  • , Karen L. Case
  • , Nancy Mcguire
  • , Amy M. Odley
  • , Li Sparks
  • , Sharon L.R. Kardia
  • , Gerald W. Dorn

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)2740-2750
Number of pages11
JournalHuman Molecular Genetics
Volume16
Issue number22
DOIs
StatePublished - Nov 15 2007
Externally publishedYes

ASJC Scopus Subject Areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Keywords

  • Heart Failure/epidemiology
  • Gene Frequency
  • Humans
  • Middle Aged
  • Gene Expression Regulation
  • Rats
  • Male
  • Survival Rate
  • Promoter Regions, Genetic/genetics
  • Case-Control Studies
  • GC Rich Sequence
  • Polymorphism, Genetic
  • GTP-Binding Protein alpha Subunits, Gs/genetics
  • Animals
  • Adolescent
  • Early Growth Response Protein 1
  • Aged, 80 and over
  • Adult
  • Female
  • Transcription, Genetic
  • Aged
  • Electrophoretic Mobility Shift Assay
  • Binding Sites
  • Black or African American/genetics

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