TY - JOUR
T1 - A comparison of rapid-scanning X-ray fluorescence mapping and magnetic resonance imaging to localize brain iron distribution
AU - McCrea, Richard P.E.
AU - Harder, Sheri L.
AU - Martin, Melanie
AU - Buist, Richard
AU - Nichol, Helen
N1 - Funding Information:
This work was funded by CIHR (Canadian Institutes for Health Research) and NSERC (National Science and Engineering Research Council) under a Collaborative Health Research Program grant to H.N. R.M. was supported by a Deans’ Scholarship from the University of Saskatchewan. We would like to acknowledge Dr. Uwe Bergmann, Martin George, and Alex Garachtchenko at SSRL for technique development, Dr. D. Mousseau, University of Saskatchewan for providing the transgenic and control mice, Bogdan Popescu and Akela Hanson for assistance in data collection. Portions of this research were carried out at the Stanford Synchrotron Radiation Laboratory, a national user facility operated by Stanford University on behalf of the U.S. Department of Energy, Office of Basic Energy Sciences. The SSRL Structural Molecular Biology Program is supported by the Department of Energy, Office of Biological and Environmental Research, and by the National Institutes of Health, National Center for Research Resources, Biomedical Technology Program.
PY - 2008/12
Y1 - 2008/12
N2 - The clinical diagnosis of many neurodegenerative disorders relies primarily or exclusively on observed behaviors rather than measurable physical tests. One of the hallmarks of Alzheimer disease (AD) is the presence of amyloid-containing plaques associated with deposits of iron, copper and/or zinc. Work in other laboratories has shown that iron-rich plaques can be seen in the mouse brain in vivo with magnetic resonance imaging (MRI) using a high-field strength magnet but this iron cannot be visualized in humans using clinical magnets. To improve the interpretation of MRI, we correlated iron accumulation visualized by X-ray fluorescence spectroscopy, an element-specific technique with T1, T2, and susceptibility weighted MR (SWI) in a mouse model of AD. We show that SWI best shows areas of increased iron accumulation when compared to standard sequences.
AB - The clinical diagnosis of many neurodegenerative disorders relies primarily or exclusively on observed behaviors rather than measurable physical tests. One of the hallmarks of Alzheimer disease (AD) is the presence of amyloid-containing plaques associated with deposits of iron, copper and/or zinc. Work in other laboratories has shown that iron-rich plaques can be seen in the mouse brain in vivo with magnetic resonance imaging (MRI) using a high-field strength magnet but this iron cannot be visualized in humans using clinical magnets. To improve the interpretation of MRI, we correlated iron accumulation visualized by X-ray fluorescence spectroscopy, an element-specific technique with T1, T2, and susceptibility weighted MR (SWI) in a mouse model of AD. We show that SWI best shows areas of increased iron accumulation when compared to standard sequences.
KW - Alzheimer disease
KW - Iron accumulation
KW - Neurodegenerative disorders
KW - X-ray fluorescent spectroscopy
UR - https://www.scopus.com/pages/publications/56549108452
UR - https://www.scopus.com/pages/publications/56549108452#tab=citedBy
U2 - 10.1016/j.ejrad.2008.04.048
DO - 10.1016/j.ejrad.2008.04.048
M3 - Article
C2 - 18635329
SN - 0720-048X
VL - 68
SP - S109-S113
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 3 SUPPL.
ER -