TY - GEN
T1 - 200 MeV proton radiography studies with a hand phantom using a prototype proton CT scanner
AU - Plautz, Tia
AU - Bashkirov, V.
AU - Feng, V.
AU - Hurley, F.
AU - Johnson, R. P.
AU - Leary, C.
AU - Macafee, S.
AU - Plumb, A.
AU - Rykalin, V.
AU - Sadrozinski, H. F.W.
AU - Schubert, K.
AU - Schulte, R.
AU - Schultze, B.
AU - Steinberg, D.
AU - Witt, M.
AU - Zatserklyaniy, A.
N1 - Author(s): Plautz, T; Bashkirov, V; Feng, V; Hurley, F; Johnson, RP; Leary, C; Macafee, S; Plumb, A; Sadrozinski, HFW; Schubert, K; Schultze, R; Steinberg, D; Witt, M; Zatserklyaniy, A | Abstract: Proton radiography generates two-dimensional projection images of an object and has applications in patient alignment and verification procedures in preparation for proton beam radiation therapy.
PY - 2013/7/8
Y1 - 2013/7/8
N2 - Proton radiography has applications in patient alignment and verification procedures for proton beam radiation therapy. In this paper, we report an experiment which used 200 MeV protons to generate proton energy-loss and scattering radiographs of a hand phantom. The experiment used the first-generation proton computed tomography (CT) scanner prototype, which was installed on the research beam line of the clinical proton synchrotron at Loma Linda University Medical Center. It was found that while both radiographs displayed anatomical details of the hand phantom, the energy-loss radiograph had a noticeably higher resolution. Nonetheless, scattering radiography may yield more contrast between soft and bone tissue than energy-loss radiography, however, this requires further study. This study contributes to the optimization of the performance of the next-generation of clinical proton CT scanners. Furthermore, it demonstrates the potential of proton imaging (proton radiography and CT), which is now within reach of becoming available as a new, potentially low-dose medical imaging modality. © 1982-2012 IEEE.
AB - Proton radiography has applications in patient alignment and verification procedures for proton beam radiation therapy. In this paper, we report an experiment which used 200 MeV protons to generate proton energy-loss and scattering radiographs of a hand phantom. The experiment used the first-generation proton computed tomography (CT) scanner prototype, which was installed on the research beam line of the clinical proton synchrotron at Loma Linda University Medical Center. It was found that while both radiographs displayed anatomical details of the hand phantom, the energy-loss radiograph had a noticeably higher resolution. Nonetheless, scattering radiography may yield more contrast between soft and bone tissue than energy-loss radiography, however, this requires further study. This study contributes to the optimization of the performance of the next-generation of clinical proton CT scanners. Furthermore, it demonstrates the potential of proton imaging (proton radiography and CT), which is now within reach of becoming available as a new, potentially low-dose medical imaging modality. © 1982-2012 IEEE.
KW - Data reduction
KW - Tomographic reconstruction of material properties
KW - proton imaging
KW - spatial resolution
KW - Protons
KW - Tomography, X-Ray Computed/instrumentation
KW - Algorithms
KW - Hand/diagnostic imaging
KW - Humans
KW - Image Processing, Computer-Assisted/methods
KW - Radiation Dosage
KW - Phantoms, Imaging
UR - https://escholarship.org/uc/item/7cz6n2m6
UR - https://www.mendeley.com/catalogue/58b48c23-dece-3ae9-a9a6-0dec73d33a8a/
U2 - 10.1109/TMI.2013.2297278
DO - 10.1109/TMI.2013.2297278
M3 - Conference contribution
C2 - 24710156
SN - 9781467320306
VL - 33
T3 - IEEE Transactions on Medical Imaging
SP - 875
EP - 881
BT - 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)
T2 - 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012
Y2 - 29 October 2012 through 3 November 2012
ER -