Richard Applegate, II, MD

Research output

Research output per year 1959 2013 2016 2017 2021 2025

• 70 Article
• 13 Review article
• 8 Chapter (peer-reviewed)
• 8 Letter
• 8 More
  • 6 Chapter
  • 1 Book
  • 1 Comment/debate

Research output per year

Research output per year

Search results

• 2025

  A Retrospective Study of Ultramassive Transfusion in Trauma Patients: Is There a Value After Which Additional Transfusions Are Futile?

  Major, F. R., Pickering, T. A., Stefanescu, K., Singh, M., Clark, D. H., Inaba, K., Nahmias, J. T., Tay-Lasso, E. L., Alvarez, C., Chen, J. L., Ahmed, F., Kaslow, O. Y., Tong, J. L., Xiao, J., Hall, E., Elkhateb, R., Bahgat, Y., Tatum, D., Simpson, J. T. & Singh, S. & 3 others, Klein, N. J., Applegate, R. L. & Kuza, C. M., 2025, (Accepted/In press) In: Anesthesia and Analgesia. 10.1213/ANE.0000000000007569.

  Research output: Contribution to journal › Article › peer-review

• Performance of pulse oximeters as a function of race compared to skin pigmentation: a single center retrospective study

  Marlar, A. I., Knabe, B. K., Taghikhan, Y., Applegate, R. L. & Fleming, N. W., Feb 2025, In: Journal of Clinical Monitoring and Computing. 39, 1, p. 119-125 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2024

  Diversity, Equity, and Inclusion in US Anesthesiology Residency Matching

  Sumarli, A. N., Pineda, L. S., Vacaru, A., Novak, E., Brandt, Z., Reynoso, E. E., Applegate, R. L. & McCabe, M. D., Nov 1 2024, In: Anesthesia and Analgesia. 139, 5, p. 913-920 8 p.

  Research output: Contribution to journal › Article › peer-review
• 2023

  Aerosol precautions and airway complications: a national prospective multicentre cohort study

  the AeroComp Trainee Research Networks & Collaborators, Jan 2023, In: Anaesthesia. 78, 1, p. 23-35 13 p.

  Research output: Contribution to journal › Article › peer-review

• Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery

  REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture) Investigators, Jan 2023, In: Annals of Internal Medicine. 176, 1, p. 952-960 9 p.

  Research output: Contribution to journal › Article › peer-review
• 2022

  Effect of lipid-lowering medications in patients with coronary artery bypass grafting surgery outcomes

  Shi, C., Zhang, Z., Goldhammer, J., Li, D., Kiaii, B., Rudriguez, V., Boyd, D., Lubarsky, D., Applegate, R. & Liu, H., Dec 2022, In: BMC Anesthesiology. 22, 1, 122.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2021

  Comparison of Oral Loading Dose to Intravenous Acetaminophen in Children for Analgesia after Tonsillectomy and Adenoidectomy: A Randomized Clinical Trial

  Lammers, C. R., Schwinghammer, A. J., Hall, B., Kriss, R. S., Aizenberg, D. A., Funamura, J. L., Senders, C. W., Nittur, V. & Applegate, R. L., Dec 1 2021, In: Anesthesia and Analgesia. 133, 6, p. 1568-1576 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Course of Illness and Outcomes in Older COVID-19 Patients Treated with HFNC: a Retrospective Analysis

  Deng, L., Lei, S., Wang, X., Jiang, F., Lubarsky, D. A., Zhang, L., Liu, D., Han, C., Zhou, D., Wang, Z., Sun, X., Zhang, Y., Cheung, C. W., Wang, S., Xia, Z., Applegate, R. L., Tang, J., Mai, Z., Liu, H. & Xia, Z., Jun 30 2021, In: Aging. 13, 12, p. 15801-15814 14 p.

  Research output: Contribution to journal › Article › peer-review

• Frailty, Race/Ethnicity, Functional Status, and Adverse Outcomes After Total Hip/Knee Arthroplasty: A Moderation Analysis

  Dharmasukrit, C., Chan, S. Y. S., Applegate, R. L., Tancredi, D. J., Harvath, T. A. & Joseph, J. G., Jun 2021, In: Journal of Arthroplasty. 36, 6, p. 1895-1903 9 p.

  Research output: Contribution to journal › Article › peer-review

• Oxygen Reserve Index: Utility as an Early Warning for Desaturation in High-Risk Surgical Patients

  Fleming, N. W., Singh, A., Lee, L. & Applegate, R. L., Mar 1 2021, In: Anesthesia and Analgesia. 132, 3, p. 770-776 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Perioperative dexmedetomidine and 5-year survival in patients undergoing cardiac surgery

  Peng, K., Shen, Y. P., Ying, Y. Y., Kiaii, B., Rodriguez, V., Boyd, D., Applegate, R. L., Lubarsky, D. A., Zhang, Z., Xia, Z., Feng, X. M., Yang, J. P., Liu, H. & Ji, F. H., Aug 2021, In: British Journal of Anaesthesia. 127, 2, p. 215-223 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Remote Ischemic Pre-conditioning in Subarachnoid Hemorrhage: A Prospective Pilot Trial

  Raval, R. N., Small, O., Magsino, K., Chakravarthy, V., Austin, B., Applegate, R. & Dorotta, I., Jun 2021, In: Neurocritical Care. 34, 3, p. 968-973 6 p.

  Research output: Contribution to journal › Article › peer-review

• Simultaneous comparison of depth of sedation performance between SedLine and BIS during general anesthesia using custom passive interface hardware: study protocol for a prospective, non-blinded, non-randomized trial

  Jones, J. H., Nittur, V. R., Fleming, N. & Applegate, R. L., Dec 2021, In: BMC Anesthesiology. 21, 1, 105.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Study of early warning for desaturation provided by Oxygen Reserve Index in obese patients

  Tsymbal, E., Ayala, S., Singh, A., Applegate, R. L. & Fleming, N. W., Aug 2021, In: Journal of Clinical Monitoring and Computing. 35, 4, p. 749-756 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2020

  Effect of Dexmedetomidine on Cardiac Surgery-Associated Acute Kidney Injury: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials

  Peng, K., Li, D., Applegate, R. L., Lubarsky, D. A., Ji, F. H. & Liu, H., Mar 2020, In: Journal of Cardiothoracic and Vascular Anesthesia. 34, 3, p. 603-613 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Impact of preoperative pectoralis plane nerve blocks for mastectomy on perioperative opioid consumption: A retrospective study

  Kim, S. Y., Avila, J., Lee, J., Lee, T., MacRes, S., Applegate, R. L., Wilson, M. D. & Zhou, J., May 2020, In: Pain Management. 10, 3, p. 159-165 7 p.

  Research output: Contribution to journal › Article › peer-review

• Multicenter comparison of three intraoperative hemoglobin trend monitoring methods

  Applegate, R. L., Applegate, P. M., Cannesson, M., Peiris, P., Ladlie, B. L. & Torp, K., Oct 1 2020, In: Journal of Clinical Monitoring and Computing. 34, 5, p. 883-892 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Perioperative Dexmedetomidine Improves Outcomes of Kidney Transplant

  Chen, J., Perez, R., de Mattos, A. M., Wang, C., Li, Z., Applegate, R. L. & Liu, H., Nov 2020, In: Clinical and Translational Science. 13, 6, p. 1279-1287 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2019

  Inhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of asphyxia induced-cardiac arrest

  Huang, L., Applegate, R., Applegate, P., Gong, L., Ocak, U., Boling, W. & Zhang, J., Sep 2019, In: Medical Gas Research. 9, 3, p. 122-126 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Retrospective Cohort Study on the Optimal Timing of Orogastric Tube/Nasogastric Tube Insertion in Infants With Pyloric Stenosis

  Lee, L. K., Burns, R. A., Dhamrait, R. S., Carter, H. F., Vadi, M. G., Grogan, T. R., Elashoff, D. A., Applegate, R. L. & Iravani, M., Oct 1 2019, In: Anesthesia and Analgesia. 129, 4, p. 1079-1086 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2018

  A comparison of midazolam and zolpidem as oral premedication in children, a prospective randomized double-blinded clinical trial

  Hanna, A. H., Ramsingh, D., Sullivan-Lewis, W., Cano, S., Leiter, P., Wallace, D., Andrews, G., Austin, B. & Applegate, R. L., Dec 2018, In: Paediatric Anaesthesia. 28, 12, p. 1109-1115 7 p.

  Research output: Contribution to journal › Article › peer-review

• A comparison of postoperative outcomes with PDA ligation in the or versus the NICU: A retrospective cohort study on the risks of transport

  Lee, L. K., Woodfin, M. Y., Vadi, M. G., Grogan, T. R., Ross, P. J., Applegate, R. L. & Iravani, M., Dec 22 2018, In: BMC Anesthesiology. 18, 1, p. 199 199.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest

  Huang, L., Applegate, R., Applegate, P., Boling, W. & Zhang, J., Jul 1 2018, In: Medical Gas Research. 8, 3, p. 73-78 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Remote limb ischemic preconditioning attenuates cerebrovascular depression during sinusoidal galvanic vestibular stimulation via α₁-adrenoceptor-protein kinase Cε-endothelial no synthase pathway in rats

  McBride, D. W., Reis, C., Zhang, J. H., Applegate, R. & Tang, J., Apr 3 2018, In: Journal of the American Heart Association. 7, 7, e007105.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2017

  Comparison of the glidescope cobalt® and storz dci® video laryngoscopes in children younger than 2 years of age during manual in-line stabilization: A randomized trainee evaluation study

  Vadi, M. G., Roddy, K. J., Ghazal, E. A., Um, M., Neiheisel, A. J. & Applegate, R. L., Jul 1 2017, In: Pediatric Emergency Care. 33, 7, p. 467-473 7 p.

  Research output: Contribution to journal › Article › peer-review

• Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury

  Kim, C. H., McBride, D. W., Raval, R., Sherchan, P., Hay, K. L., Gren, E. C. K., Kelln, W., Lekic, T., Hayes, W. K., Bull, B. S., Applegate, R., Tang, J. & Zhang, J. H., Jan 19 2017, In: Scientific Reports. 7, 40821.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Extreme Plasma Dilution Decreases Heparin and Protamine Cardiopulmonary Bypass Requirements: A Case Report on a Jehovah’s Witness Patient: A case report on a jehovah’s witness patient

  Chang, E., Gatling, J. W., Bode, S., Herrmann, P. C., Bull, B. S. & Applegate, R. L., Jan 6 2017, In: A & A case reports. 8

  Research output: Contribution to journal › Article › peer-review

• Is it the time to reconsider the choice of valves for cardiac surgery: Mechanical or bioprosthetic?

  Applegate, P. M., Boyd, W. D., Applegate, R. L. & Liu, H., Aug 26 2017, In: Journal of Biomedical Research. 31, 5, p. 373-376 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Use of Esophageal Hemoximetry to Assess the Effect of Packed Red Blood Cell Transfusion on Gastrointestinal Oxygenation in Newborn Infants

  Vora, F. M., Gates, J., Gerard, K., Hanson, S., Applegate, R. L. & Blood, A. B., Jul 1 2017, In: American Journal of Perinatology. 34, 8, p. 735-741 7 p.

  Research output: Contribution to journal › Article › peer-review
• 2016

  Advanced monitoring is associated with fewer alarm events during planned moderate procedure-related sedation: A 2-part pilot trial

  Applegate, R. L., Lenart, J., Malkin, M., Meineke, M. N., Qoshlli, S., Neumann, M., Jacobson, J. P., Kruger, A., Ching, J., Hassanian, M. & Um, M., Apr 1 2016, In: Anesthesia and Analgesia. 122, 4, p. 1070-1078 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• An experimental model of vasovagal syncope induces cerebral hypoperfusion and fainting-like behavior in awake rats

  McBride, D. W., Reis, C., Frank, E., Klebe, D. W., Zhang, J. H., Applegate, R. & Tang, J., Sep 2016, In: PLoS ONE. 11, 9, p. e0163280 e0163280.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Beta blockade and clinical outcomes in aneurysmal subarachnoid hemorrhage

  Chang, M. M., Raval, R. N., Southerland, J. J., Adewumi, D. A., Bahjri, K. A., Samuel, R. K., Woods, R. O., Ajayi, O. O., Lee, B. S., Hsu, F. P. K., Applegate, R. L. & Dorotta, I. R., Dec 1 2016, In: Open Neurology Journal. 10, p. 155-163 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Comparison of indirect video laryngoscopes in children younger than two years of age: A randomized trainee evaluation study

  Vadi, M. G., Ghazal, E. A., Halverson, B. & Applegate, R. L., Feb 2016, In: Middle East Journal of Anesthesiology. 23, 4, p. 401-410 10 p.

  Research output: Contribution to journal › Article › peer-review

• Comparison of web-based and face-to-face interviews for application to an anesthesiology training program: a pilot study

  Vadi, M. G., Malkin, M. R., Lenart, J., Stier, G. R., Gatling, J. W. & Applegate, R. L., Apr 3 2016, In: International journal of medical education. 7, p. 102-108 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Continuous Noninvasive Hemodynamic Monitoring in an Infant With Tetra-Amelia.

  Vadi, M. G., Ghazal, E. A., Malkin, M. R., Ayodeji, A. & Applegate, R. L., Jan 9 2016, In: A A Case Reports. 7, 6, p. 123-4 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Intraoperative Red Blood Cell Transfusion in Infant Heart Transplant Patients Is Not Associated with Worsened Outcomes

  Carter, H. F., Lau, C., Juma, D., Wells, B. & Applegate, R. L., May 1 2016, In: Anesthesia and Analgesia. 122, 5, p. 1567-1577 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Management of Near-Complete Airway Obstruction Caused by a Vallecular Cyst in an Infant Using a Tongue Tip Traction Suture

  Wong, C. M., Ghazal, E. A., Dyleski, R. A. & Applegate, R. L., Jan 15 2016, In: A & A case reports. 6, 2, p. 31-33 3 p.

  Research output: Contribution to journal › Article › peer-review

• The Relationship between Oxygen Reserve Index and Arterial Partial Pressure of Oxygen during Surgery

  Applegate, R. L., Dorotta, I. L., Wells, B., Juma, D. & Applegate, P. M., Sep 1 2016, In: Anesthesia and Analgesia. 123, 3, p. 626-633 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2015

  Phosphoinositide 3-kinase gamma contributes to neuroinflammation in a rat model of surgical brain injury

  Huang, L., Sherchan, P., Wang, Y., Reis, C., Applegate, R. L., Tang, J. & Zhang, J. H., Jul 22 2015, In: Journal of Neuroscience. 35, 29, p. 10390-10401 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2014

  Analgesic effectiveness of acetaminophen for primary cleft palate repair in young children: A randomized placebo controlled trial

  Nour, C., Ratsiu, J., Singh, N., Mason, L., Ray, A., Martin, M., Hassanian, M., Uhler, J. & Applegate, R. L., Jun 2014, In: Paediatric Anaesthesia. 24, 6, p. 574-581 8 p.

  Research output: Contribution to journal › Article › peer-review

• Anti-neutrophil antibody enhances the neuroprotective effects of G-CSF by decreasing number of neutrophils in hypoxic ischemic neonatal rat model

  Doycheva, D. M., Hadley, T., Li, L., Applegate, R. L., Zhang, J. H. & Tang, J., Sep 2014, In: Neurobiology of Disease. 69, p. 192-199 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Cognitive dysfunction following desflurane versus sevoflurane general anesthesia in elderly patients: A randomized controlled trial 6

  Meineke, M., Applegate, R. L., Rasmussen, T., Anderson, D., Azer, S., Mehdizadeh, A., Kim, A. & Allard, M., Mar 25 2014, In: Medical Gas Research. 4, 1, 6.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2013

  Association of plasma dilution with cardiopulmonary bypass-associated bleeding and morbidity

  Brauer, S. D., Applegate, R. L., Jameson, J. J., Hay, K. L., Lauer, R. E., Herrmann, P. C. & Bull, B. S., Oct 2013, In: Journal of Cardiothoracic and Vascular Anesthesia. 27, 5, p. 845-852 8 p.

  Research output: Contribution to journal › Article › peer-review

• Evaluation of multiple modes of oximetry monitoring as an index of splanchnic blood flow in a newborn lamb model of hypoxic, ischemic, and hemorrhagic stress.

  Applegate, R. L., Ramsingh, D. S., Dorotta, I., Sanghvi, C. & Blood, A. B., Jun 2013, In: Shock. 39, 6, p. 501-506 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Granulocyte-colony Stimulating Factor in Combination with Stem Cell Factor Confers Greater Neuroprotection after Hypoxic-Ischemic Brain Damage in the Neonatal Rats than a Solitary Treatment

  Doycheva, D., Shih, G., Chen, H., Applegate, R., Zhang, J. H. & Tang, J., Apr 2013, In: Translational Stroke Research. 4, 2, p. 171-178 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Impact of rocuronium vs succinylcholine neuromuscular blocking drug choice for laparoscopic pyloromyotomy: Is there a difference in time to transport to recovery?

  Ghazal, E., Amin, A., Wu, A., Felema, B. & Applegate, R. L., Apr 2013, In: Paediatric Anaesthesia. 23, 4, p. 316-321 6 p.

  Research output: Contribution to journal › Article › peer-review

• Isoflurane post-treatment ameliorates GMH-induced brain injury in neonatal rats

  Leitzke, A. S., Rolland, W. B., Krafft, P. R., Lekic, T., Klebe, D., Flores, J. J., Van Allen, N. R., Applegate, R. L. & Zhang, J. H., Dec 2013, In: Stroke. 44, 12, p. 3587-3590 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Outcome impact of goal directed fluid therapy during high risk abdominal surgery in low to moderate risk patients: A randomized controlled trial

  Ramsingh, D. S., Sanghvi, C., Gamboa, J., Cannesson, M. & Applegate, R. L., Jun 2013, In: Journal of Clinical Monitoring and Computing. 27, 3, p. 249-257 9 p.

  Research output: Contribution to journal › Article › peer-review

• Telemedicine pre-anesthesia evaluation: A randomized pilot trial

  Applegate, R. L., Gildea, B., Patchin, R., Rook, J. L., Wolford, B., Nyirady, J., Dawes, T. A., Faltys, J., Ramsingh, D. S. & Stier, G., Mar 1 2013, In: Telemedicine and e-Health. 19, 3, p. 211-216 6 p.

  Research output: Contribution to journal › Article › peer-review

• The Perioperative Management of Asthma

  Applegate, R., Lauer, R., Lenart, J., Gatling, J. & Vadi, M., Jan 1 2013, In: Journal of Allergy and Therapy. 01, S11

  Research output: Contribution to journal › Article › peer-review