Kin-Hing William Lau, PhD

Research output

Research output per year 1982 1995 1996 2002 2006 2007 2013 2016 2025

• 153 Article
• 11 Review article
• 11 Other contribution
• 5 Meeting abstract
• 15 More
  • 4 Chapter
  • 4 Patent
  • 2 Poster
  • 2 Digital or Visual Products
  • 1 Paper
  • 1 Letter
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2025

  Conditional Deletion of Gremlin-1 in Cathepsin K-expressing Mature Osteoclasts Altered the Skeletal Response to Calcium Depletion in Sex-Dependent Manner

  Sheng, M. H. C., Rundle, C. H., Baylink, D. J. & Lau, K. H. W., Dec 2025, In: Calcified Tissue International. 116, 1, 28.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Microvesicles Released by Osteoclastic Cells Exhibited Chondrogenic, Osteogenic, and Anti-Inflammatory Activities: An Evaluation of the Feasibility of Their Use for Treatment of Osteoarthritis in a Mouse Model

  Sheng, M. H. C., Rundle, C. H. & Lau, K. H. W., Feb 2025, In: Cells. 14, 3, 193.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Overexpression of miR17 ~ 92 in Myeloid Cells in Mice Increased Bone Mass Through Reduced Bone Resorption and Increased Bone Formation in Sex-Dependent Manner

  Sheng, M. H. C., Stiffel, V. M., Taipia, J., Rundle, C. H. & Lau, K. H. W., Dec 2025, In: Calcified Tissue International. 116, 1, 9.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2022

  A Novel EphA4 Signaling-Based Therapeutic Strategy for Osteoarthritis in Mice

  Stiffel, V. M., Rundle, C. H., Sheng, M. H. C., Das, S. & Lau, K. H. W., Apr 2022, In: Journal of Bone and Mineral Research. 37, 4, p. 660-674 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation

  Ahmed, A. S. I., Sheng, M. H. C., Lau, K. H. W., Wilson, S. M., Wongwarawat, D., Tang, X., Ghahramanpouri, M., Nehme, A., Xu, Y., Abdipour, A., Zhang, X. B., Wasnik, S. & Baylink, D. J., May 2022, In: American Journal of Physiology - Cell Physiology. 322, 5, p. C977-C990

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Defective bone repletion in aged Balb/cBy mice was caused by impaired osteoblastic differentiation

  Sheng, M. H. C., Lau, K. H. W., Rundle, C. H., Alsunna, A., Wilson, S. M. & Baylink, D. J., Nov 2022, In: Journal of Bone and Mineral Metabolism. 40, 6, p. 900-913 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2020

  A Mouse Noninvasive Intraarticular Tibial Plateau Compression Loading-Induced Injury Model of Posttraumatic Osteoarthritis

  Stiffel, V., Rundle, C. H., Sheng, M. H. C., Das, S. & Lau, K. H. W., Feb 1 2020, In: Calcified Tissue International. 106, 2, p. 158-171 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The EphA4 Signaling is Anti-catabolic in Synoviocytes but Pro-anabolic in Articular Chondrocytes

  Stiffel, V. M., Thomas, A., Rundle, C. H., Sheng, M. H. C. & Lau, K. H. W., Dec 1 2020, In: Calcified Tissue International. 107, 6, p. 576-592 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Unique anabolic action of stem cell gene therapy overexpressing PDGFB-DSS6 fusion protein in OVX osteoporosis mouse model

  Chen, W., Wasnik, S., Fu, Y., Aranda, L., Rundle, C. H., Lau, K. H. W., Baylink, D. J. & Zhang, X., Jun 2020, In: Bone Reports. 12, p. 100236 100236.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2019

  Cyclooxygenase 2 augments osteoblastic but suppresses chondrocytic differentiation of CD90⁺ skeletal stem cells in fracture sites

  Wasnik, S., Lakhan, R., Baylink, D. J., Rundle, C. H., Xu, Y., Zhang, J., Qin, X., Lau, K. H. W., Carreon, E. E. & Tang, X., Jul 31 2019, In: Science Advances. 5, 7, p. eaaw2108 eaaw2108.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• In vivo generation of gut-homing regulatory T cells for the suppression of colitis

  Xu, Y., Cheng, Y., Baylink, D. J., Wasnik, S., Goel, G., Huang, M., Cao, H., Qin, X., Lau, K. H. W., Chan, C., Koch, A., Pham, L. H., Zhang, J., Li, C. H., Wang, X., Berumen, E. C., Smith, J. & Tang, X., Jun 15 2019, In: Journal of Immunology. 202, 12, p. 3447-3457 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis

  Li, C. H., Tang, X., Wasnik, S., Wang, X., Zhang, J., Xu, Y., Lau, K. H. W., Nguyen, H. B. & Baylink, D. J., Dec 2 2019, In: BMC Infectious Diseases. 19, 1, p. 1020 1020.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2018

  1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites

  Wasnik, S., Rundle, C. H., Baylink, D. J., Yazdi, M. S., Carreon, E. E., Xu, Y., Qin, X., Lau, K. H. W. & Tang, X., Sep 6 2018, In: JCI insight. 3, 17

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Deficient arginase II expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice

  Choudry, M., Tang, X., Santorian, T., Wasnik, S., Xiao, J., Xing, W., Lau, K. H. W., Mohan, S., Baylink, D. J. & Qin, X., Sep 2018, In: Immunology. 155, 1, p. 85-98 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2017

  Conditional Disruption of miR17∼92 in Osteoclasts Led to Activation of Osteoclasts and Loss of Trabecular Bone in Part Through Suppression of the miR17-Mediated Downregulation of Protein-Tyrosine Phosphatase-oc in Mice

  Lau, K. H. W., Stiffel, V. M., Rundle, C. H., Amoui, M., Tapia, J., White, T. D. & Sheng, M. H. C., Oct 1 2017, In: JBMR Plus. 1, 2, p. 73-85 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Unique regenerative mechanism to replace bone lost during dietary bone depletion in weanling mice

  Sheng, M. H. C., William Lau, K. H., Lakhan, R., Ahmed, A. S. I., Rundle, C. H., Biswanath, P. & Baylink, D. J., Apr 1 2017, In: Endocrinology. 158, 4, p. 714-729 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2016

  Conditional deletion of IGF-I in osteocytes unexpectedly accelerates bony union of the fracture gap in mice

  Lau, K. H. W., Rundle, C. H., Zhou, X. D., Baylink, D. J. & Sheng, M. H. C., Nov 1 2016, In: Bone. 92, p. 18-28 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Generation of mesenchymal stem cells by blood cell reprogramming

  Chen, W., Baylink, D. J., Lau, K. H. W. & Zhang, X. B., Jan 1 2016, In: Current Stem Cell Research and Therapy. 11, 2, p. 114-121 8 p.

  Research output: Contribution to journal › Article › peer-review

• MicroRNA223 promotes pathogenic T-cell development and autoimmune inflammation in central nervous system in mice

  Satoorian, T., Li, B., Tang, X., Xiao, J., Xing, W., Shi, W., Lau, K. H. W., Baylink, D. J. & Qin, X., Aug 1 2016, In: Immunology. 148, 4, p. 326-338 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Opposing effects of Sca-1⁺ cell-based systemic FGF2 gene transfer strategy on lumbar versus caudal vertebrae in the mouse

  Lau, K. H. W., Chen, S. T., Wang, X., Mohan, S., Wergedal, J. E., Kesavan, C., Srivastava, A. K., Gridley, D. S. & Hall, S. L., Jun 1 2016, In: Gene Therapy. 23, 6, p. 500-509 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2015

  An Osteoclastic Transmembrane Protein-Tyrosine Phosphatase Enhances Osteoclast Activity in Part by Dephosphorylating EphA4 in Osteoclasts

  Lau, K. H. W., Amoui, M., Stiffel, V., Chen, S. T. & Sheng, M. H. C., Aug 1 2015, In: Journal of Cellular Biochemistry. 116, 8, p. 1785-1796 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Local administration of AAV-DJ pseudoserotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice

  Lakhan, R., Baylink, D. J., Lau, K. H. W., Tang, X., Sheng, M. H. C., Rundle, C. H. & Qin, X., Sep 5 2015, In: Gene Therapy. 22, 9, p. 721-728 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Osteocyte-derived insulin-like growth factor I is not essential for the bone repletion response in mice

  Lau, K. H. W., Baylink, D. J. & Sheng, M. H. C., Jan 30 2015, In: PLoS ONE. 10, 1, p. e0115897 e0115897.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• PDGFB-based stem cell gene therapy increases bone strength in the mouse

  Chen, W., Baylink, D. J., Brier-Jones, J., Neises, A., Kiroyan, J. B., Rundle, C. H., Lau, K. H. W. & Zhang, X. B., Jul 21 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 29, p. E3893-E3900

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Targeted 25-hydroxyvitamin D₃ 1α-hydroxylase adoptive gene therapy ameliorates DSS-induced colitis without causing hypercalcemia in mice

  Li, B., Baylink, D. J., Walter, M. H., Lau, K. H. W., Meng, X., Wang, J., Cherkas, A., Tang, X. & Qin, X., Mar 2015, In: Molecular Therapy. 23, 2, p. 339-351 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2014

  Direct lentiviral-cyclooxygenase 2 application to the tendon-bone interface promotes osteointegration and enhances return of the pull-out tensile strength of the tendon graft in a rat model of biceps tenodesis

  Rundle, C. H., Chen, S. T., Coen, M. J., Wergedal, J. E., Stiffel, V. & Lau, K. H. W., May 21 2014, In: PLoS ONE. 9, 5, e98004.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• EphA4 receptor is a novel negative regulator of osteoclast activity

  Stiffel, V., Amoui, M., Sheng, M. H. C., Mohan, S. & Lau, K. H. W., Apr 2014, In: Journal of Bone and Mineral Research. 29, 4, p. 804-819 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Microarray Analysis of Gene Expression Reveals that Cyclo-oxygenase-2 Gene Therapy Up-regulates Hematopoiesis and Down-regulates Inflammation During Endochondral Bone Fracture Healing

  Lau, K.-H. W., Popa, N. L. & Rundle, C. H., Aug 1 2014, In: Journal of Bone Metabolism. 21, 3, p. 169-88 20 p.

  Research output: Contribution to journal › Article › peer-review

• Role of Osteocyte-derived Insulin-Like Growth Factor I in Developmental Growth, Modeling, Remodeling, and Regeneration of the Bone

  Sheng, M. H. C., Lau, K. H. W. & Baylink, D. J., Feb 1 2014, In: Journal of Bone Metabolism. 21, 1, p. 41-54 14 p.

  Research output: Contribution to journal › Article › peer-review

• Urokinase plasminogen activator gene deficiency inhibits fracture cartilage remodeling

  Popa, N. L., Wergedal, J. E., Lau, K. H. W., Mohan, S. & Rundle, C. H., Mar 2014, In: Journal of Bone and Mineral Metabolism. 32, 2, p. 124-135 12 p.

  Research output: Contribution to journal › Article › peer-review
• 2013

  1,25-Dihydroxyvitamin D3 Suppresses TLR8 Expression and TLR8-Mediated Inflammatory Responses in Monocytes In Vitro and Experimental Autoimmune Encephalomyelitis In Vivo

  Li, B., Baylink, D. J., Deb, C., Zannetti, C., Rajaallah, F., Xing, W., Walter, M. H., Lau, K. H. W. & Qin, X., Mar 14 2013, In: PLoS ONE. 8, 3, p. e58808 e58808.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Cellular and molecular mechanisms of accelerated fracture healing by COX2 gene therapy. Studies in a mouse model of multiple fractures.

  Lau, K. H. W., Kothari, V., Das, A., Zhang, X. B. & Baylink, D. J., Apr 2013, In: Bone. 53, 2, p. 369-381 13 p.

  Research output: Contribution to journal › Article › peer-review

• Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice

  Sheng, M. H. C., Zhou, X. D., Bonewald, L. F., Baylink, D. J. & Lau, K. H. W., Jan 2013, In: Bone. 52, 1, p. 133-144 12 p.

  Research output: Contribution to journal › Article › peer-review

• Efficient Generation of Integration-Free iPS Cells from Human Adult Peripheral Blood Using BCL-XL Together with Yamanaka Factors

  Su, R. J., Baylink, D. J., Neises, A., Kiroyan, J. B., Meng, X., Payne, K. J., Tschudy-Seney, B., Duan, Y., Appleby, N., Kearns-Jonker, M., Gridley, D. S., Wang, J., Lau, K. H. W. & Zhang, X. B., Dec 2013, In: PLoS ONE. 8, 5, p. e64496 e64496.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity

  William Lau, K. H., Baylink, D. J., Zhou, X. D., Rodriguez, D., Bonewald, L. F., Li, Z., Ruffoni, D., Müller, R., Kesavan, C. & Sheng, M. H. C., Jul 15 2013, In: American Journal of Physiology - Endocrinology and Metabolism. 305, 2, p. E271-E281

  Research output: Contribution to journal › Article › peer-review

• Rapid and efficient reprogramming of human fetal and adult blood CD34 + cells into mesenchymal stem cells with a single factor

  Meng, X., Su, R. J., Baylink, D. J., Neises, A., Kiroyan, J. B., Lee, W. Y. W., Payne, K. J., Gridley, D. S., Wang, J., Lau, K. H. W., Li, G. & Zhang, X. B., May 2013, In: Cell Research. 23, 5, p. 658-672 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Serum 1,25-Dihydroxyvitamin D: An Outcome Prognosticator in Human Sepsis

  Nguyen, H. B., Eshete, B., Lau, K. H. W., Sai, A., Villarin, M. & Baylink, D., May 31 2013, In: PLoS ONE. 8, 5, e64348.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2012

  An osteoclastic protein-tyrosine phosphatase regulates the β₃-integrin, syk, and shp1 signaling through respective src-dependent phosphorylation in osteoclasts

  William Lau, K. H., Stiffel, V. & Amoui, M., Jun 1 2012, In: American Journal of Physiology - Cell Physiology. 302, 11, p. 1676-1686 11 p.

  Research output: Contribution to journal › Article › peer-review

• Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation

  Linares, G. R., Brommage, R., Powell, D. R., Xing, W., Chen, S. T., Alshbool, F. Z., Lau, K. H. W., Wergedal, J. E. & Mohan, S., Jul 2012, In: Journal of Bone and Mineral Research. 27, 7, p. 1553-1565 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Efficient reprogramming of human cord blood CD34⁺ cells into induced pluripotent stem cells with OCT4 and SOX2 alone

  Meng, X., Neises, A., Su, R. J., Payne, K. J., Ritter, L., Gridley, D. S., Wang, J., Sheng, M., Lau, K. H. W., Baylink, D. J. & Zhang, X. B., Feb 2012, In: Molecular Therapy. 20, 2, p. 408-416 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Erythroid promoter confines FGF2 expression to the marrow after hematopoietic stem cell gene therapy and leads to enhanced endosteal bone formation

  Meng, X., Baylink, D. J., Sheng, M., Wang, H., Gridley, D. S., Lau, K. H. W. & Zhang, X. B., May 18 2012, In: PLoS ONE. 7, 5, p. e37569 e37569.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice

  Sheng, M. H. C., Wergedal, J. E., Mohan, S., Amoui, M., Baylink, D. J. & Lau, K. H. W., Apr 20 2012, In: PLoS ONE. 7, 4, p. e35280 e35280.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2011

  Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading

  Kesavan, C., Wergedal, J. E., William Lau, K. H. & Mohan, S., Dec 2011, In: American Journal of Physiology - Endocrinology and Metabolism. 301, 6, p. E1191-E1197

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Lentiviral-based BMP4 in vivo gene transfer strategy increases pull-out tensile strength without an improvement in the osteointegration of the tendon graft in a rat model of biceps tenodesis

  Coen, M. J., Chen, S. T., Rundle, C. H., Wergedal, J. E. & Lau, K. H. W., Oct 2011, In: Journal of Gene Medicine. 13, 10, p. 511-521 11 p.

  Research output: Contribution to journal › Article › peer-review

• Stem cell antigen-1 positive cell-based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice

  Hall, S. L., Chen, S. T., Wergedal, J. E., Gridley, D. S., Mohan, S. & Lau, K. H. W., Feb 2011, In: Journal of Gene Medicine. 13, 2, p. 77-88 12 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Leptin receptor (Lepr) is a negative modulator of bone mechanosensitivity and genetic variations in Lepr may contribute to the differential osteogenic response to mechanical stimulation in the C57BL/6J and C3H/HeJ pair of mouse strains

  Kapur, S., Amoui, M., Kesavan, C., Wang, X., Mohan, S., Baylink, D. J. & Lau, K. H. W., Nov 26 2010, In: Journal of Biological Chemistry. 285, 48, p. 37607-37618 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2009

  Marrow stromal cell-based cyclooxygenase 2 Ex vivo gene-transfer strategy surprisingly lacks bone-regeneration effects and suppresses the bone-regeneration action of bone morphogenetic protein 4 in a mouse critical-sized calvarial defect model

  Lau, K. H. W., Gysin, R., Chen, S. T., Wergedal, J. E., Baylink, D. J. & Mohan, S., Oct 2009, In: Calcified Tissue International. 85, 4, p. 356-367 12 p.

  Research output: Contribution to journal › Article › peer-review

• Stem cell antigen-1⁺ cell-based bone morphogenetic protein-4 gene transfer strategy in mice failed to promote endosteal bone formation

  Hall, S. L., Chen, S. T., Gysin, R., Gridley, D. S., Mohan, S. & Lau, K. H. W., 2009, In: Journal of Gene Medicine. 11, 10, p. 877-888 12 p.

  Research output: Contribution to journal › Article › peer-review

• Targeted transgenic expression of an osteoclastic transmembrane protein-tyrosine phosphatase in cells of osteoclastic lineage increases bone resorption and bone loss in male young adult mice

  Sheng, M. H. C., Amoui, M., Stiffel, V., Srivastava, A. K., Wergedal, J. E. & Lau, K. H. W., Apr 24 2009, In: Journal of Biological Chemistry. 284, 17, p. 11531-11545 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2008

  Bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis

  Rundle, C. H., Wang, X., Sheng, M. H. C., Wergedal, J. E., Lau, K. H. W. & Mohan, S., Nov 2008, In: Bone. 43, 5, p. 880-888 9 p.

  Research output: Contribution to journal › Article › peer-review